6N59
 
 | | 1.0 Angstrom crystal structure of [FeFe]-hydrogenase | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Zadvornyy, O.A, Keable, S.M, Artz, J.H, Peters, J.W. | | Deposit date: | 2018-11-21 | | Release date: | 2019-12-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.02 Å) | | Cite: | Tuning Catalytic Bias of Hydrogen Gas Producing Hydrogenases.
J.Am.Chem.Soc., 142, 2020
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8ALN
 | | CO-bound [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI) at 1.34 Angstrom | | Descriptor: | Binuclear [FeFe], di(thiomethyl)amine, carbon monoxide, ... | | Authors: | Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2022-08-01 | | Release date: | 2022-12-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8PVM
 | | formaldehyde-inhibited [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant C299D | | Descriptor: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FORMYL GROUP, ... | | Authors: | Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2023-07-18 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Insights into the Molecular Mechanism of Formaldehyde Inhibition of [FeFe]-Hydrogenases.
J.Am.Chem.Soc., 145, 2023
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3C8Y
 | | 1.39 Angstrom crystal structure of Fe-only hydrogenase | | Descriptor: | 2 IRON/2 SULFUR/3 CARBONYL/2 CYANIDE/WATER/METHYLETHER CLUSTER, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... | | Authors: | Pandey, A.S, Lemon, B.J, Peters, J.W. | | Deposit date: | 2008-02-14 | | Release date: | 2008-04-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Dithiomethylether as a ligand in the hydrogenase h-cluster.
J.Am.Chem.Soc., 130, 2008
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8AP2
 | | cyanide-bound [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI) at 1.39 Angstrom | | Descriptor: | Binuclear [FeFe], di(thiomethyl)amine, carbon monoxide, ... | | Authors: | Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2022-08-09 | | Release date: | 2022-12-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8AJ6
 | | cyanide-bound [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI) | | Descriptor: | Binuclear [FeFe], di(thiomethyl)amine, carbon monoxide, ... | | Authors: | Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2022-07-27 | | Release date: | 2022-12-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8AIO
 | | CO-bound [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI) | | Descriptor: | Binuclear [FeFe], di(thiomethyl)amine, carbon monoxide, ... | | Authors: | Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2022-07-26 | | Release date: | 2022-12-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8QM3
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6NAC
 | | Crystal structure of [FeFe]-hydrogenase I (CpI) solved with single pulse free electron laser data | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Cohen, A.E, Davidson, C.M, Zadvornyy, O.A, Keable, S.M, Lyubimov, A.Y, Song, J, McPhillips, S.E, Soltis, S.M, Peters, J.W. | | Deposit date: | 2018-12-05 | | Release date: | 2019-12-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Tuning Catalytic Bias of Hydrogen Gas Producing Hydrogenases.
J.Am.Chem.Soc., 142, 2020
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4XDD
 | | Apo [FeFe]-Hydrogenase CpI | | Descriptor: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... | | Authors: | Esselborn, J, Hofmann, E, Kurisu, G, Happe, T. | | Deposit date: | 2014-12-19 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.599 Å) | | Cite: | A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.
Chem Sci, 7, 2016
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8CJY
 | | [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant S357T | | Descriptor: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... | | Authors: | Brocks, C, Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2023-02-13 | | Release date: | 2023-10-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A Dynamic Water Channel Affects O 2 Stability in [FeFe]-Hydrogenases.
Chemsuschem, 17, 2024
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4XDC
 | | Active semisynthetic [FeFe]-hydrogenase CpI with aza-dithiolato-bridged [2Fe] cofactor | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Esselborn, J, Hofmann, E, Kurisu, G, Happe, T. | | Deposit date: | 2014-12-19 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.
Chem Sci, 7, 2016
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7QHF
 | | [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI), variant G302S | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Brocks, C, Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2021-12-12 | | Release date: | 2023-09-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | A Dynamic Water Channel Affects O 2 Stability in [FeFe]-Hydrogenases.
Chemsuschem, 2023
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5BYQ
 | | Semisynthetic [FeFe]-hydrogenase CpI with oxodithiolato-bridged [2Fe] cofactor | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Esselborn, J, Muraki, N, Engelbrecht, V, Hofmann, E, Kurisu, G, Happe, T. | | Deposit date: | 2015-06-10 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.
Chem Sci, 7, 2016
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6YF4
 | | [FeFe]-hydrogenase I from Clostridium pasteurianum (CpI), variant E279D | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Duan, J, Hofmann, E, Happe, T. | | Deposit date: | 2020-03-25 | | Release date: | 2020-09-02 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | The roles of long-range proton-coupled electron transfer in the directionality and efficiency of [FeFe]-hydrogenases.
Proc.Natl.Acad.Sci.USA, 117, 2020
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1FEH
 | | FE-ONLY HYDROGENASE FROM CLOSTRIDIUM PASTEURIANUM | | Descriptor: | 2 IRON/2 SULFUR/5 CARBONYL/2 WATER INORGANIC CLUSTER, FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, ... | | Authors: | Peters, J.W, Lanzilotta, W.N, Lemon, B.J, Seefeldt, L.C. | | Deposit date: | 1998-10-28 | | Release date: | 1999-01-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution.
Science, 282, 1998
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5BYR
 | | Semisynthetic [FeFe]-hydrogenase CpI with propane-dithiolato-bridged [2Fe] cofactor | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Esselborn, J, Muraki, N, Engelbrecht, V, Hofmann, E, Kurisu, G, Happe, T. | | Deposit date: | 2015-06-10 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.
Chem Sci, 7, 2016
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5BYS
 | | Semisynthetic [FeFe]-hydrogenase CpI with sulfur-dithiolato-bridged [2Fe] cofactor | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Esselborn, J, Muraki, N, Engelbrecht, V, Hofmann, E, Kurisu, G, Happe, T. | | Deposit date: | 2015-06-10 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.
Chem Sci, 7, 2016
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6N6P
 | | Crystal structure of [FeFe]-hydrogenase in the presence of 7 mM Sodium dithionite | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Zadvornyy, O.A, Keable, S.M, Peters, J.W. | | Deposit date: | 2018-11-26 | | Release date: | 2019-12-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Tuning Catalytic Bias of Hydrogen Gas Producing Hydrogenases.
J.Am.Chem.Soc., 142, 2020
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6GM8
 | | [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant E282Q | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Duan, J, Esselborn, J, Hofmann, E, Winkler, M, Happe, T. | | Deposit date: | 2018-05-24 | | Release date: | 2018-11-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases.
Nat Commun, 9, 2018
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6GM4
 | | [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant S319A | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Duan, J, Esselborn, J, Hofmann, E, Winkler, M, Happe, T. | | Deposit date: | 2018-05-24 | | Release date: | 2018-11-07 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases.
Nat Commun, 9, 2018
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6GLZ
 | | [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant C299D | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Duan, J, Esselborn, J, Hofmann, E, Winkler, M, Happe, T. | | Deposit date: | 2018-05-24 | | Release date: | 2018-11-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases.
Nat Commun, 9, 2018
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6GM1
 | | [FeFe]-hydrogenase CpI from Clostridium pasteurianum, variant E282A | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Duan, J, Esselborn, J, Hofmann, E, Winkler, M, Happe, T. | | Deposit date: | 2018-05-24 | | Release date: | 2018-11-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases.
Nat Commun, 9, 2018
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5OEF
 | | Active semisynthetic [FeFe]-hydrogenase CpI with aza-diselenato-bridged [2Fe] cofactor | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Kertess, L, Esselborn, J, Happe, T, Hofmann, E. | | Deposit date: | 2017-07-07 | | Release date: | 2017-11-29 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Chalcogenide substitution in the [2Fe] cluster of [FeFe]-hydrogenases conserves high enzymatic activity.
Dalton Trans, 46, 2017
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6H63
 | | Semisynthetic [FeFe]-hydrogenase CpI with ethanedithiolate [2Fe] cofactor | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, Iron hydrogenase 1, ... | | Authors: | Duan, J, Winkler, M, Hofmann, E, Happe, T. | | Deposit date: | 2018-07-26 | | Release date: | 2019-09-18 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Geometry of the Catalytic Active Site in [FeFe]-Hydrogenase Is Determined by Hydrogen Bonding and Proton Transfer
Acs Catalysis, 2019
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