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PDB: 46 results

4GMU
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BU of 4gmu by Molmil
Structure of rat cytosolic PEPCK Ld_1g in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-16
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
3MOE
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BU of 3moe by Molmil
The structure of rat cytosolic PEPCK mutant A467G in complex with Beta-Sulfopyruvate and GTP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity .
Biochemistry, 49, 2010
3DTB
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BU of 3dtb by Molmil
The structure of rat cytosolic PEPCK in complex with phosphoglycolate and GDP
Descriptor: 2-PHOSPHOGLYCOLIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BICARBONATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4GNQ
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BU of 4gnq by Molmil
Structure of rat cytosolic PEPCK Ld_3g in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-17
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
4YW9
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BU of 4yw9 by Molmil
Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and GTP
Descriptor: 3-sulfanylpyridine-2-carboxylic acid, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Balan, M.D, Johnson, T.A, Mcleod, M.J, Lotosky, W.R, Holyoak, T.
Deposit date:2015-03-20
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid.
Biochemistry, 54, 2015
3DT4
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BU of 3dt4 by Molmil
The structure of rat cytosolic PEPCK in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5FH2
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BU of 5fh2 by Molmil
The structure of rat cytosolic PEPCK variant E89Q in complex with GTP
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2015-12-21
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Biochemistry, 55, 2016
6P5O
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BU of 6p5o by Molmil
The structure of rat cytosolic PEPCK in complex with 3-(carboxymethylthiol)-picolinic acid
Descriptor: 3-[(carboxymethyl)sulfanyl]pyridine-2-carboxylic acid, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Mcleod, M.J, Holyoak, T.
Deposit date:2019-05-30
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase.
Biochemistry, 58, 2019
5FH4
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BU of 5fh4 by Molmil
The structure of rat cytosolic PEPCK variant E89D in complex with beta-sulfopyruvate and GTP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2015-12-21
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Biochemistry, 55, 2016
4GNO
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BU of 4gno by Molmil
Structure of rat cytosolic PEPCK Ld_3g in complex with Beta-Sulfopyruvate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-17
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
4GNM
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BU of 4gnm by Molmil
Structure of rat cytosolic PEPCK Ld_2g in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-17
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
3DT2
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BU of 3dt2 by Molmil
The structure of rat cytosolic PEPCK in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT7
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BU of 3dt7 by Molmil
The structure of rat cytosolic PEPCK in complex with beta-sulfopyruvate and GTP
Descriptor: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4YWB
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BU of 4ywb by Molmil
Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and oxalic acid
Descriptor: 3-sulfanylpyridine-2-carboxylic acid, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Balan, M.D, Johnson, T.A, Lotosky, W.R, Mcleod, M.J, Holyoak, T.
Deposit date:2015-03-20
Release date:2015-09-23
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid.
Biochemistry, 54, 2015
5FH5
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BU of 5fh5 by Molmil
The structure of rat cytosolic PEPCK variant E89Q in complex with phosphoglycolate and GDP
Descriptor: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2015-12-21
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Biochemistry, 55, 2016
5FH1
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BU of 5fh1 by Molmil
The structure of rat cytosolic PEPCK variant E89D in complex with GTP
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2015-12-21
Release date:2016-12-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Biochemistry, 55, 2016
4YW8
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BU of 4yw8 by Molmil
Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid
Descriptor: 1,2-ETHANEDIOL, 3-sulfanylpyridine-2-carboxylic acid, MANGANESE (II) ION, ...
Authors:Balan, M.D, Johnson, T.A, Mcleod, M.J, Lotosky, W.R, Holyoak, T.
Deposit date:2015-03-20
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid.
Biochemistry, 54, 2015
5FH3
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BU of 5fh3 by Molmil
The structure of rat cytosolic PEPCK variant E89A in complex with oxalic acid and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2015-12-21
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Biochemistry, 55, 2016
5FH0
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BU of 5fh0 by Molmil
The structure of rat cytosolic PEPCK variant E89A complex with GTP
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2015-12-21
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Biochemistry, 55, 2016
2QF2
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BU of 2qf2 by Molmil
Rat cytosolic PEPCK in complex with oxaloacetic acid and GDP.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, OXALOACETATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2007-06-26
Release date:2007-08-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.
Biochemistry, 46, 2007
4GNL
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BU of 4gnl by Molmil
Structure of rat cytosolic PEPCK Ld_2g in complex with PEP and GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-17
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
4GMM
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BU of 4gmm by Molmil
Structure of rat cytosolic PEPCK Ld_1g in complex with Beta-Sulfopyruvate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-16
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.736 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
4GNP
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BU of 4gnp by Molmil
Structure of rat cytosolic PEPCK Ld_3g in complex with PEP and GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-17
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.744 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
4GMW
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BU of 4gmw by Molmil
Structure of rat cytosolic PEPCK Ld_1g in complex with PEP and GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2012-08-16
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
Biochemistry, 51, 2012
6YI9
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BU of 6yi9 by Molmil
Crystal structure of the rat cytosolic PCK1, acetylated on Lys244
Descriptor: 1,2-ETHANEDIOL, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Authors:Latorre-Muro, P, Baeza, J, Hurtado-Guerrero, R, Hicks, T, Delso, I, Hernandez-Ruiz, C, Velazquez-Campoy, A, Lawton, A.J, Angulo, J, Denu, J.M, Carrodeguas, J.A.
Deposit date:2020-04-01
Release date:2020-12-23
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity.
J.Biol.Chem., 296, 2021

 

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