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PDB: 6 results
6OHM
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BU of 6ohm by Molmil
Structure of tungstate bound human Phospholipase D2 catalytic domain
Descriptor: GLYCEROL, Phospholipase D2, SULFATE ION, ...
Authors:Metrick, C.M, Chodaparambil, J.V.
Deposit date:2019-04-06
Release date:2020-02-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat.Chem.Biol., 16, 2020
6OHO
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BU of 6oho by Molmil
Structure of human Phospholipase D2 catalytic domain
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Phospholipase D2, ...
Authors:Metrick, C.M, Chodaparambil, J.V.
Deposit date:2019-04-06
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat.Chem.Biol., 16, 2020
6OHP
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BU of 6ohp by Molmil
Structure of compound 1 (halopemide) bound human Phospholipase D2 catalytic domain
Descriptor: GLYCEROL, N-{2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl}-4-fluorobenzamide, Phospholipase D2, ...
Authors:Metrick, C.M, Chodaparambil, J.V.
Deposit date:2019-04-06
Release date:2020-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat.Chem.Biol., 16, 2020
6OHQ
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BU of 6ohq by Molmil
Structure of compound 4 bound human Phospholipase D2 catalytic domain
Descriptor: 4-fluoro-N-{(2S)-1-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl}benzamide, Phospholipase D2, SULFATE ION
Authors:Metrick, C.M, Chodaparambil, J.V.
Deposit date:2019-04-06
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.694 Å)
Cite:Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat.Chem.Biol., 16, 2020
7SVP
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BU of 7svp by Molmil
Structure of compound 34 bound to human Phospholipase D2 catalytic domain
Descriptor: 1-(1-{(2S)-1-[(3R,5R)-3,5-dimethylpiperazin-1-yl]-1-oxopropan-2-yl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, Phospholipase D2
Authors:Metrick, C.M, Chodaparambil, J.V.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
Acs Med.Chem.Lett., 13, 2022
6OHS
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BU of 6ohs by Molmil
Structure of compound 3 (ML299) bound human Phospholipase D2 catalytic domain
Descriptor: 4-bromo-N-{(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl}benzamide, Phospholipase D2
Authors:Metrick, C.M, Chodaparambil, J.V.
Deposit date:2019-04-06
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat.Chem.Biol., 16, 2020

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