7WED
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6ZOZ
| Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Locked State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
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7WE8
| SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | Authors: | Wang, X, Wang, L. | Deposit date: | 2021-12-23 | Release date: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
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7N9A
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7EJ5
| Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RBD-chAb45, ... | Authors: | Yang, T.J, Yu, P.Y, Wu, H.C, Hsu, S.T.D. | Deposit date: | 2021-04-01 | Release date: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 To Be Published
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7EAZ
| Cryo-EM structure of SARS-CoV-2 Spike D614G variant, one RBD-up conformation 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Yang, T.J, Yu, P.Y, Chang, Y.C, Hsu, S.T.D. | Deposit date: | 2021-03-08 | Release date: | 2021-06-23 | Last modified: | 2022-01-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation. J.Biol.Chem., 297, 2021
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6ZWV
| Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: 3 Closed RBDs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Ke, Z, Qu, K, Nakane, T, Xiong, X, Cortese, M, Zila, V, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-28 | Release date: | 2020-08-05 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature, 588, 2020
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7EB4
| Cryo-EM structure of SARS-CoV-2 Spike D614G variant, two RBD-up conformation 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Yang, T.J, Yu, P.Y, Chang, Y.C, Hsu, S.T.D. | Deposit date: | 2021-03-08 | Release date: | 2021-06-23 | Last modified: | 2022-01-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation. J.Biol.Chem., 297, 2021
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7K8Z
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7DX3
| S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and no PD bound) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Yan, R.H, Zhang, Y.Y, Li, Y.N, Ye, F.F, Guo, Y.Y, Xia, L, Zhong, X.Y, Chi, X.M, Zhou, Q. | Deposit date: | 2021-01-18 | Release date: | 2021-03-31 | Last modified: | 2021-06-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2. Cell Res., 31, 2021
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7JZM
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7BNN
| Open conformation of D614G SARS-CoV-2 spike with 1 Erect RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Benton, D.J, Wrobel, A.G, Rosenthal, P.B, Gamblin, S.J. | Deposit date: | 2021-01-22 | Release date: | 2021-02-03 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 118, 2021
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8HXJ
| BANAL-20-52 Spike trimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Xu, G. | Deposit date: | 2023-01-04 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The selective effect of fecal-oral transmission on the S proteins of bat SARS-CoV-2 related coronaviruses in favor of stability over infectivity To Be Published
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7TL9
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7TL1
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8I9B
| S-ECD (Omicron BA.2.75) in complex with PD of ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | Authors: | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | Deposit date: | 2023-02-06 | Release date: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for the enhanced infectivity and immune evasion of Omicron subvariants To Be Published
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7CZR
| S protein of SARS-CoV-2 in complex bound with P5A-1B8_2B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c542_heavy_IGHV3-53_IGHD3-10_IGHJ6,IGH@ protein, ... | Authors: | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | Deposit date: | 2020-09-09 | Release date: | 2021-03-10 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
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8DZI
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8DV2
| SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion, Spike glycoprotein | Authors: | QCRG Structural Biology Consortium, Remesh, S.G, Merz, G.E, Brilot, A.F, Chio, U, Verba, K.A. | Deposit date: | 2022-07-27 | Release date: | 2022-08-31 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31, 2023
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7R11
| Dissociated S1 domain of Beta Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | Authors: | Benton, D.J, Wrobel, A.G, Gamblin, S.J. | Deposit date: | 2022-02-02 | Release date: | 2022-03-09 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Evolution of the SARS-CoV-2 spike protein in the human host. Nat Commun, 13, 2022
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7R16
| Beta Variant SARS-CoV-2 Spike with 1 Erect RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Benton, D.J, Wrobel, A.G, Gamblin, S.J. | Deposit date: | 2022-02-02 | Release date: | 2022-03-09 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Evolution of the SARS-CoV-2 spike protein in the human host. Nat Commun, 13, 2022
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7R0Z
| Dissociated S1 domain of Alpha Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | Authors: | Benton, D.J, Wrobel, A.G, Gamblin, S.J. | Deposit date: | 2022-02-02 | Release date: | 2022-03-09 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Evolution of the SARS-CoV-2 spike protein in the human host. Nat Commun, 13, 2022
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7X6A
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7CWU
| SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Wang, X, Wang, N. | Deposit date: | 2020-08-31 | Release date: | 2020-12-16 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure-based development of human antibody cocktails against SARS-CoV-2. Cell Res., 31, 2021
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8QQ0
| SARS-CoV-2 S protein bound to neutralising antibody UZGENT_A3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Remaut, H, Reiter, D, Vandenkerckhove, L, Acar, D.D, Witkowski, W, Gerlo, S. | Deposit date: | 2023-10-03 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted. Ebiomedicine, 100, 2024
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