9NFR
 
 | | Crystal structure of CRBN-DDB1 and MRT-23227 in complex with VAV1 | | Descriptor: | (3R)-3-{2-chloro-4'-[(1-methyl-1H-pyrazol-3-yl)methoxy][1,1'-biphenyl]-3-yl}piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | | Authors: | Trenh, P, Bunker, R.D, Lucas, X, Gainza, P, Tsai, J.H.C. | | Deposit date: | 2025-02-21 | | Release date: | 2025-07-09 | | Last modified: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
Science, 389, 2025
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9NGT
 | | Crystal structure of CRBN-DDB1 and FPFT-2216 in complex with mTOR | | Descriptor: | (3S)-3-[(4M)-4-(4-methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | | Authors: | Petzold, G, Trenh, P, Bunker, R.D, Tsai, J.H.C. | | Deposit date: | 2025-02-22 | | Release date: | 2025-07-09 | | Last modified: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
Science, 389, 2025
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9NFQ
 | | Crystal structure of CRBN-DDB1 and MRT-3486 in complex with NEK7 | | Descriptor: | (3S)-N-{[(4R)-3-(2,4-dioxo-1,3-diazinan-1-yl)imidazo[1,2-a]pyridin-7-yl]methyl}-2-(phenylmethanesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, DNA damage-binding protein 1, ... | | Authors: | Quan, C, Petzold, G, Bunker, R.D, Wiedmer, L, Gainza, P, Tsai, J.H.C. | | Deposit date: | 2025-02-21 | | Release date: | 2025-07-09 | | Last modified: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
Science, 389, 2025
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