PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Bruton's tyrosine kinase L528W mutant in complex with 5-(piperidin-1-yl)-3-{[4-(piperidin-4-yl)phenyl]amino}pyrazine-2-carboxamide
Descriptor:	1,2-ETHANEDIOL, 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide, Tyrosine-protein kinase BTK
Authors:	Gajewski, S.
Deposit date:	2023-03-01
Release date:	2024-01-31
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. Science, 383, 2024

Bruton's tyrosine kinase in complex with 5-(piperidin-1-yl)-3-{[4-(piperidin-4-yl)phenyl]amino}pyrazine-2-carboxamide
Descriptor:	1,2-ETHANEDIOL, 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide, CHLORIDE ION, ...
Authors:	Gajewski, S.
Deposit date:	2023-03-01
Release date:	2024-01-31
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. Science, 383, 2024