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Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi
Descriptor:	Obtusifoliol, PROTOPORPHYRIN IX CONTAINING FE, Sterol 14alpha-demethylase
Authors:	Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I.
Deposit date:	2018-02-01
Release date:	2018-10-24
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3.18 Å)
Cite:	Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51. J. Biol. Chem., 293, 2018