9KXR
 
 | | Crystal structure of E. coli tryptophanyl-tRNA synthetase complexed with chuangxinmycin and tryptophanyl-5'-AMP | | Descriptor: | (5~{S},6~{R})-5-methyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | | Authors: | Ren, Y, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2024-12-07 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KWH
 | | Crystal structure of S. aureus tryptophanyl-tRNA synthetase complexed with chuangxinmycin | | Descriptor: | (5~{S},6~{R})-5-methyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, Tryptophan--tRNA ligase | | Authors: | Ren, Y, Qiao, H, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2024-12-05 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KWW
 | | Crystal structure of S. aureus tryptophanyl-tRNA synthetase complexed with 3-demethylchuangxinmycin | | Descriptor: | (6~{R})-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(11),3,8(12),9-tetraene-6-carboxylic acid, Tryptophan--tRNA ligase | | Authors: | Ren, Y, Qiao, H, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2024-12-06 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KY3
 | | Crystal structure of E. coli tryptophanyl-tRNA synthetase complexed with 3-demethylchuangxinmycin and tryptophanyl-5'-AMP | | Descriptor: | (6~{R})-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(11),3,8(12),9-tetraene-6-carboxylic acid, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | | Authors: | Ren, Y, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2024-12-07 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KVC
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9M1F
 | | Crystal structure of E. coli tryptophanyl-tRNA synthetase complexed with chuangxinmycin and ATP in closed-closed state | | Descriptor: | (5~{S},6~{R})-5-methyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | | Authors: | Ren, Y, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2025-02-25 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KY9
 | | Crystal structure of E. coli tryptophanyl-tRNA synthetase complexed with 3-methylchuangxinmycin and tryptophanyl-5'-AMP | | Descriptor: | (6~{R})-5,5-dimethyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | | Authors: | Ren, Y, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2024-12-08 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KXB
 | | Crystal structure of S. aureus tryptophanyl-tRNA synthetase complexed with 3-methylchuangxinmycin | | Descriptor: | (6~{R})-5,5-dimethyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, Tryptophan--tRNA ligase | | Authors: | Ren, Y, Qiao, H, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2024-12-06 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9M1G
 | | Crystal structure of E. coli tryptophanyl-tRNA synthetase complexed with chuangxinmycin and ATP in open-closed state | | Descriptor: | (5~{S},6~{R})-5-methyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ren, Y, Wang, S, Liu, W, Fang, P. | | Deposit date: | 2025-02-25 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin.
Rsc Chem Biol, 6, 2025
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9KW0
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