9MXT
 
 | | Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 tetramer in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile (JLJ648), a Non-nucleoside Inhibitor | | Descriptor: | 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H | | Authors: | Hollander, K, Devarkar, S.C, Tang, S, Ma, S, Xiong, Y, Jorgensen, W.L, Anderson, K.S. | | Deposit date: | 2025-01-20 | | Release date: | 2025-09-10 | | Last modified: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Npj Drug Discov, 2, 2025
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9MXR
 | | Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 Homodimer in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy] phenoxy}naphthalene-2-carbonitrile (JLJ648), a Non-nucleoside Inhibitor | | Descriptor: | 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H | | Authors: | Hollander, K, Devarkar, S.C, Tang, S, Ma, S, Xiong, Y, Jorgensen, W.L, Anderson, K.S. | | Deposit date: | 2025-01-20 | | Release date: | 2025-09-10 | | Last modified: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Npj Drug Discov, 2, 2025
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9MXB
 | | Crystal Structure of WT HIV-1 Reverse Transcriptase in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy] phenoxy}naphthalene-2-carbonitrile (JLJ648), a non-nucleoside inhibitor | | Descriptor: | 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, CHLORIDE ION, Reverse transcriptase/ribonuclease H, ... | | Authors: | Hollander, K, Jorgensen, W.L, Anderson, K.S. | | Deposit date: | 2025-01-17 | | Release date: | 2025-09-10 | | Last modified: | 2025-09-17 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Npj Drug Discov, 2, 2025
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9MXS
 | | Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 Homodimer in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy] phenoxy}naphthalene-2-carbonitrile, a Non-nucleoside Inhibitor, with an Additional Pocket of Density | | Descriptor: | 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H | | Authors: | Hollander, K, Devarkar, S.C, Tang, S, Ma, S, Xiong, Y, Jorgensen, W.L, Anderson, K.S. | | Deposit date: | 2025-01-20 | | Release date: | 2025-09-10 | | Last modified: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Npj Drug Discov, 2, 2025
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9MXQ
 | | Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 Homodimer | | Descriptor: | Reverse transcriptase/ribonuclease H | | Authors: | Hollander, K, Devarkar, S.C, Tang, S, Ma, S, Xiong, Y, Anderson, K.S. | | Deposit date: | 2025-01-20 | | Release date: | 2025-09-10 | | Last modified: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Npj Drug Discov, 2, 2025
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