9HYO
 
 | | CRYSTAL STRUCTURE OF THE SMARCA2-VCB-COMPLEX WITH PROTAC P4 | | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[7-(5-bromanyl-4-oxidanylidene-2,3-dihydro-1,3-benzoxazin-2-yl)-4-[cyclopropyl(methyl)amino]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | Authors: | Roy, M.J. | | Deposit date: | 2025-01-10 | | Release date: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (3.74 Å) | | Cite: | Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes.
Nat Commun, 16, 2025
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9HYN
 | | CRYSTAL STRUCTURE OF THE SMARCA2-VCB-COMPLEX WITH PROTAC P1 | | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[2-[2-[4-[(6-bromanyl-3-methyl-5-oxidanylidene-4~{H}-imidazo[1,2-a]quinazolin-2-yl)methyl]piperazin-1-yl]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | Authors: | Bader, G, Wolkerstorfer, B. | | Deposit date: | 2025-01-10 | | Release date: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes.
Nat Commun, 16, 2025
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9HYP
 | | CRYSTAL STRUCTURE OF THE SMARCA2-VCB-COMPLEX WITH PROTAC P5 | | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-6~{H}-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]butoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | Authors: | Roy, M.J. | | Deposit date: | 2025-01-10 | | Release date: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes.
Nat Commun, 16, 2025
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