9CUE
 
 | | Human STING H232R variant bound to ABZI | | Descriptor: | Stimulator of interferon genes protein, benzyl (3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-1,3-benzimidazol-1-yl}propyl)carbamate | | Authors: | Sack, J.S, Critton, D.A. | | Deposit date: | 2024-07-26 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
Nat Commun, 16, 2025
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9CUB
 | | Human STING G230A/R293Q variant bound to diABZI-a1 | | Descriptor: | 1,1'-[(2E)-but-2-ene-1,4-diyl]bis{2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-1,3-benzimidazole-5-carboxamide}, Stimulator of interferon genes protein | | Authors: | Critton, D.A. | | Deposit date: | 2024-07-26 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
Nat Commun, 16, 2025
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9CUD
 | | Human STING G230A/R293Q variant bound to diABZI-i | | Descriptor: | (2E)-1-[(2E)-4-{(2E)-5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino]-3-methyl-2,3-dihydro-1H-1,3-benzimidazol-1-yl}-2,3-dimethylbut-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino]-7-[(3-methoxyphenyl)methoxy]-3-methyl-2,3-dihydro-1H-1,3-benzimidazole-5-carboxamide, Stimulator of interferon genes protein | | Authors: | Critton, D.A. | | Deposit date: | 2024-07-26 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
Nat Commun, 16, 2025
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9CUA
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9CUC
 | | Human STING G230A/R293Q variant bound to THIQi | | Descriptor: | (3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid, Stimulator of interferon genes protein | | Authors: | Critton, D.A. | | Deposit date: | 2024-07-26 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
Nat Commun, 16, 2025
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