9CT4
 
 | | HsSTING with diABZI and C53, curved conformation | | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-1,3-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-1,3-benzimidazole-5-carboxamide, Stimulator of interferon genes protein | | Authors: | Gharpure, A, Sulpizio, A, Lairson, L.L, Ward, A.B. | | Deposit date: | 2024-07-24 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Distinct oligomeric assemblies of STING induced by non-nucleotide agonists.
Nat Commun, 16, 2025
|
|
9CT3
 | | HsSTING with SR-717 and C53 | | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, Stimulator of interferon genes protein | | Authors: | Gharpure, A, Sulpizio, A, Lairson, L.L, Ward, A.B. | | Deposit date: | 2024-07-24 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Distinct oligomeric assemblies of STING induced by non-nucleotide agonists.
Nat Commun, 16, 2025
|
|
9CT6
 | | HsSTING with diABZI and C53, apart conformation | | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-1,3-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-1,3-benzimidazole-5-carboxamide, Stimulator of interferon genes protein | | Authors: | Gharpure, A, Sulpizio, A, Lairson, L.L, Ward, A.B. | | Deposit date: | 2024-07-24 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Distinct oligomeric assemblies of STING induced by non-nucleotide agonists.
Nat Commun, 16, 2025
|
|
9CT5
 | | HsSTING with diABZI and C53, together conformation | | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-1,3-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-1,3-benzimidazole-5-carboxamide, Stimulator of interferon genes protein | | Authors: | Gharpure, A, Sulpizio, A, Lairson, L.L, Ward, A.B. | | Deposit date: | 2024-07-24 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Distinct oligomeric assemblies of STING induced by non-nucleotide agonists.
Nat Commun, 16, 2025
|
|
