9AS4
 
 | | Global reconstruction of 5-HT2AR bound to LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS3
 | | Local refinement of 5-HT2AR bound to LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS5
 | | Local refinement of 5-HT2AR bound to Mescaline in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2-(3,4,5-trimethoxyphenyl)ethan-1-amine, 5-hydroxytryptamine receptor 2A | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS8
 | | Global reconstruction of 5-HT2AR bound to psilocin in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS9
 | | Local refinement of 5-HT2AR bound to RS130-180 in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2,5-dimethoxy-N,N-dimethyl-4-{2-[({2-[(prop-2-yn-1-yl)oxy]phenyl}methyl)amino]ethyl}aniline, 5-hydroxytryptamine receptor 2A | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS6
 | | Global reconstruction of 5-HT2AR bound to mescaline in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2-(3,4,5-trimethoxyphenyl)ethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9ARX
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9ASA
 | | Global reconstruction of 5-HT2AR bound to RS130-180 in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2,5-dimethoxy-N,N-dimethyl-4-{2-[({2-[(prop-2-yn-1-yl)oxy]phenyl}methyl)amino]ethyl}aniline, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS2
 | | Global reconstruction of 5-HT2AR bound to DMT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2-(1H-indol-3-yl)-N,N-dimethylethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9ARY
 | | Global reconstruction 5-HT2AR bound to 5-HT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9ARZ
 | | Local refinement of 5-HT2AR bound to 2-bromo-LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2-bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8beta-carboxamide, 5-hydroxytryptamine receptor 2A | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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9AS7
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9AS1
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9AS0
 | | Global reconstruction of 5-HT2AR bound to 2-bromo-LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2-bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8beta-carboxamide, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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