9CUX
 
 | | Crystal Structure of SETDB1 Tudor domain in complex with UNC100016 | | Descriptor: | (2E)-N-(4-{[6-(dimethylamino)hexyl]amino}-2-{[5-(dimethylamino)pentyl]amino}quinazolin-6-yl)but-2-enamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ... | | Authors: | Silva, M, Dong, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-07-26 | | Release date: | 2024-10-02 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.
Nat Commun, 16, 2025
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9CUW
 | | Crystal Structure of SETDB1 Tudor domain in complex with UNC100013 | | Descriptor: | (2E)-4-(dimethylamino)-N-(4-{[6-(dimethylamino)hexyl]amino}-2-{[5-(dimethylamino)pentyl]amino}quinazolin-6-yl)but-2-enamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ... | | Authors: | Silva, M, Dong, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-07-26 | | Release date: | 2024-10-02 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.
Nat Commun, 16, 2025
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