8QM5
 
 | | Potential drug binding sites for translation initiation factor eIF4E | | Descriptor: | 1-(4-chlorophenyl)cyclopentane-1-carboxylic acid, Eukaryotic translation initiation factor 4E, TRIETHYLENE GLYCOL | | Authors: | Cleasby, A. | | Deposit date: | 2023-09-21 | | Release date: | 2025-01-15 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.889 Å) | | Cite: | Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Nat Commun, 15, 2024
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8QM7
 | | Potential drug binding sites for translation initiation factor eIF4E | | Descriptor: | (2~{R})-2-[(1~{R})-1-[4-(2-fluorophenyl)-2-(2-hydroxyethylamino)phenyl]propoxy]propan-1-ol, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Cleasby, A. | | Deposit date: | 2023-09-21 | | Release date: | 2025-01-15 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.191 Å) | | Cite: | Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Nat Commun, 15, 2024
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8QM8
 | | Potential drug binding sites for translation initiation factor eIF4E | | Descriptor: | (2~{R})-2-[(1~{S})-1-[4-(2-fluorophenyl)-2-(2-hydroxyethylamino)phenyl]propoxy]propan-1-ol, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Cleasby, A. | | Deposit date: | 2023-09-21 | | Release date: | 2025-01-15 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.585 Å) | | Cite: | Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Nat Commun, 15, 2024
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8QM9
 | | Potential drug binding sites for translation initiation factor eIF4E | | Descriptor: | (2~{R})-2-[(1~{S})-1-[4-(2-fluorophenyl)-2-(2-hydroxyethylamino)phenyl]propoxy]propan-1-ol, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Cleasby, A. | | Deposit date: | 2023-09-21 | | Release date: | 2025-01-15 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.973 Å) | | Cite: | Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Nat Commun, 15, 2024
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8QM6
 | | Potential drug binding sites for translation initiation factor eIF4E | | Descriptor: | (1~{R})-1-[4-(2-fluorophenyl)phenyl]ethanol, (1~{S})-1-[4-(2-fluorophenyl)phenyl]ethanol, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Cleasby, A. | | Deposit date: | 2023-09-21 | | Release date: | 2025-01-15 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Nat Commun, 15, 2024
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8QM4
 | | Potential drug binding sites for translation initiation factor eIF4E | | Descriptor: | 3-phenylphenol, DIMETHYL SULFOXIDE, Eukaryotic translation initiation factor 4E, ... | | Authors: | Cleasby, A. | | Deposit date: | 2023-09-21 | | Release date: | 2025-01-15 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.849 Å) | | Cite: | Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Nat Commun, 15, 2024
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