9JUT
 
 | | X-ray crystal structure of Y16524 in EP300 | | Descriptor: | (6~{S})-1-(3-chloranyl-4-methoxy-phenyl)-6-[4-(3-methyl-1,2-benzoxazol-5-yl)-1-[(2~{S})-2-morpholin-4-ylpropyl]imidazol-2-yl]piperidin-2-one, Histone acetyltransferase p300 | | Authors: | Hu, J, Zhang, C, Luo, G, Tang, X, Wu, T, Shen, H, Zhao, X, Wu, X, Smaill, J, Zhang, Y, Xu, Y, Xiang, Q. | | Deposit date: | 2024-10-08 | | Release date: | 2025-03-12 | | Last modified: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia.
Acta Pharmacol.Sin., 46, 2025
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9JUY
 | | X-ray crystal structure of Y16513 in CBP | | Descriptor: | (5~{S})-1-(3-chloranyl-4-methoxy-phenyl)-5-[4-(3-methyl-1,2-benzoxazol-5-yl)-1-[(2~{S})-2-morpholin-4-ylpropyl]imidazol-2-yl]pyrrolidin-2-one, CREB-binding protein, DIMETHYL SULFOXIDE | | Authors: | Hu, J, Zhang, C, Luo, G, Tang, X, Wu, T, Shen, H, Zhao, X, Wu, X, Smaill, J, Zhang, Y, Xu, Y, Xiang, Q. | | Deposit date: | 2024-10-08 | | Release date: | 2025-03-12 | | Last modified: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia.
Acta Pharmacol.Sin., 46, 2025
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9JUU
 | | X-ray crystal structure of Y16515 in CBP | | Descriptor: | (5~{S})-1-(3-chloranyl-4-methoxy-phenyl)-5-[4-(3-methyl-1,2-benzoxazol-5-yl)-1-[(2~{R})-2-morpholin-4-ylpropyl]imidazol-2-yl]pyrrolidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein, ... | | Authors: | Hu, J, Zhang, C, Luo, G, Tang, X, Wu, T, Shen, H, Zhao, X, Wu, X, Smaill, J, Zhang, Y, Xu, Y, Xiang, Q. | | Deposit date: | 2024-10-08 | | Release date: | 2025-03-12 | | Last modified: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia.
Acta Pharmacol.Sin., 46, 2025
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