9EJS
 
 | | Bruton's tyrosine kinase with mutations in the activation loop in complex with compound PTI52 | | Descriptor: | 4-{4-amino-1-[(3R)-1-(cyclopropanecarbonyl)piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-(4-cyclopropylpyridin-2-yl)benzamide, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK | | Authors: | Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. | | Deposit date: | 2024-11-28 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
J.Am.Chem.Soc., 147, 2025
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9EJX
 | | Bruton's tyrosine kinase with mutations in the activation loop in complex with compound PTI42 | | Descriptor: | Tyrosine-protein kinase BTK, {(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}(cyclopropyl)methanone | | Authors: | Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. | | Deposit date: | 2024-11-29 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
J.Am.Chem.Soc., 147, 2025
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9EJJ
 | | Bruton's tyrosine kinase in complex with compound PTI55 | | Descriptor: | 4-{4-amino-1-[(3R)-1-(cyclopropanecarbonyl)piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(trifluoromethoxy)pyridin-2-yl]benzamide, Tyrosine-protein kinase BTK | | Authors: | Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. | | Deposit date: | 2024-11-28 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
J.Am.Chem.Soc., 147, 2025
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9EJR
 | | Bruton's tyrosine kinase in complex with compound PTI52 | | Descriptor: | 4-{4-amino-1-[(3R)-1-(cyclopropanecarbonyl)piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-(4-cyclopropylpyridin-2-yl)benzamide, Tyrosine-protein kinase BTK | | Authors: | Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. | | Deposit date: | 2024-11-28 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
J.Am.Chem.Soc., 147, 2025
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9ME2
 | | Bruton's tyrosine kinase with mutations in the activation loop in complex with compound A110162 | | Descriptor: | 3-(4-phenoxyphenyl)-1-[(3S)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Tyrosine-protein kinase BTK | | Authors: | Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. | | Deposit date: | 2024-12-05 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (3.38 Å) | | Cite: | Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
J.Am.Chem.Soc., 147, 2025
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9ME3
 | | Bruton's tyrosine kinase with mutations in the activation loop in complex with compound P301390 | | Descriptor: | 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Tyrosine-protein kinase BTK | | Authors: | Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
J.Am.Chem.Soc., 147, 2025
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