9GBJ
 
 | | KRAS G12D in complex with covalent inhibitor | | Descriptor: | 1-[(3S)-1-[2-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]-6-[(1S)-1-[(2S)-1-methylpyrrolidin-2-yl]ethoxy]pyrimidin-4-yl]pyrrolidin-3-yl]-3-[1-(methoxymethyl)cyclopropyl]urea, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Sirocchi, L.S, Zak, K.M, Wilding, B. | | Deposit date: | 2024-07-31 | | Release date: | 2025-04-30 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.712 Å) | | Cite: | Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRAS G12D .
J.Am.Chem.Soc., 147, 2025
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