9HB7
 
 | | Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128 | | Descriptor: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 2 | | Authors: | Schuetz, A, Gogolin, A, Pfeifer, J, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | Deposit date: | 2024-11-05 | | Release date: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.95518756 Å) | | Cite: | Selectivity and Safety Characterization of a Xanthine-Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis.
Acs Pharmacol Transl Sci, 8, 2025
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9HB8
 | | Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor KM-06-098 | | Descriptor: | 3-ethyl-8-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 2 | | Authors: | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | Deposit date: | 2024-11-05 | | Release date: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.896342 Å) | | Cite: | Selectivity and Safety Characterization of a Xanthine-Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis.
Acs Pharmacol Transl Sci, 8, 2025
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9HE3
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP778902 | | Descriptor: | (2~{S})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 | | Authors: | Schuetz, A, Heinemann, U. | | Deposit date: | 2024-11-13 | | Release date: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (2.58925915 Å) | | Cite: | Selectivity and Safety Characterization of a Xanthine-Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis.
Acs Pharmacol Transl Sci, 8, 2025
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