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Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor
Descriptor:	4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide, Tyrosine-protein kinase JAK3
Authors:	Sack, J.S.
Deposit date:	2019-02-11
Release date:	2019-05-22
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.33 Å)
Cite:	Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. Acs Med.Chem.Lett., 10, 2019