PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Crystal structure of human KRAS G12C covalently bound to a phthalazine inhibitor
Descriptor:	1-{4-[7-chloro-6-(2-fluoro-6-hydroxyphenyl)-4-phenylphthalazin-1-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:	Mohr, C.
Deposit date:	2019-06-24
Release date:	2019-12-25
Last modified:	2020-01-22
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. J.Med.Chem., 63, 2020

Crystal structure of human KRAS G12C covalently bound to a quinazolinone inhibitor
Descriptor:	6-chloro-7-(2-fluoro-6-hydroxyphenyl)-4-(4-propanoylpiperazin-1-yl)-1-[2-(propan-2-yl)phenyl]quinazolin-2(1H)-one, CALCIUM ION, GTPase KRas, ...
Authors:	Mohr, C, Whittington, D.A.
Deposit date:	2019-06-24
Release date:	2019-12-25
Last modified:	2020-01-22
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. J.Med.Chem., 63, 2020