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PDB: 5 results
9N3R
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BU of 9n3r by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3N
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BU of 9n3n by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 3
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3O
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BU of 9n3o by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 14
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3Q
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BU of 9n3q by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 51
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3P
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BU of 9n3p by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 30
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025

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PDB entries from 2025-04-02

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