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Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24
Descriptor:	4-acetyl-3-ethyl-N-(3-(3-(hydroxyamino)-3-oxopropyl)phenyl)-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
Authors:	Huegle, M.
Deposit date:	2020-11-10
Release date:	2021-10-06
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J.Med.Chem., 64, 2021