PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

Factor XIA in complex with the inhibitor methyl (4-{6-[(1S)-2-[(3R)-1-acetylpiperidin-3-yl]-1-({(2E)-3-[5-chloro-2- (1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl) carbamate
Descriptor:	1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:	Sheriff, S.
Deposit date:	2018-01-02
Release date:	2018-03-07
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. Bioorg. Med. Chem. Lett., 28, 2018

FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(5E,8S)-8-[(4S)-4-(3-chlorophenyl)-2-oxopiperidin-1-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate
Descriptor:	1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:	Sheriff, S.
Deposit date:	2019-05-20
Release date:	2019-09-18
Last modified:	2021-05-12
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Bioorg.Med.Chem.Lett., 29, 2019

FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(5E,8S)-8-[(6R)-6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate
Descriptor:	1,2-ETHANEDIOL, Coagulation factor XI, MET-ASP-ASP-ASP-ASP-LYS-MET-ASP-ASN-GLU-CYS-THR-THR-LYS-ILE-LYS-PRO-ARG, ...
Authors:	Sheriff, S.
Deposit date:	2019-05-20
Release date:	2019-09-18
Last modified:	2021-05-12
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Bioorg.Med.Chem.Lett., 29, 2019