PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 7)
Descriptor:	4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide, Tyrosine-protein kinase JAK3
Authors:	Sack, J.S.
Deposit date:	2017-06-21
Release date:	2017-10-11
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.61 Å)
Cite:	Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017

CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 9)
Descriptor:	6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino}-N-methylpyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4
Authors:	Sack, J.S.
Deposit date:	2017-06-21
Release date:	2017-10-11
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017

CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 4)
Descriptor:	4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4
Authors:	Sack, J.S.
Deposit date:	2017-06-21
Release date:	2017-10-11
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017