PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Descriptor:	25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6H)-one, Protein-tyrosine kinase 2-beta
Authors:	Newby, Z.E.
Deposit date:	2016-10-17
Release date:	2016-12-21
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.9849 Å)
Cite:	Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency. Bioorg. Med. Chem. Lett., 26, 2016

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Descriptor:	N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide, Protein-tyrosine kinase 2-beta
Authors:	Newby, Z.E.
Deposit date:	2016-10-17
Release date:	2017-11-29
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.117 Å)
Cite:	Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency. Bioorg. Med. Chem. Lett., 26, 2016