9FEG
 
 | | PARP15 in complex with a quinazolin-4-one inhibitor | | Descriptor: | (2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ... | | Authors: | Bosetti, C, Lehtio, L. | | Deposit date: | 2024-05-20 | | Release date: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.
Eur.J.Med.Chem., 288, 2025
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8S60
 | | Tankyrase 2 in complex with a quinazolin-4-one inhibitor | | Descriptor: | 8-nitro-2-[4-(trifluoromethyl)phenyl]-3H-quinazolin-4-one, GLYCEROL, Poly [ADP-ribose] polymerase tankyrase-2, ... | | Authors: | Bosetti, C, Paakkonen, J, Lehtio, L. | | Deposit date: | 2024-02-26 | | Release date: | 2025-03-12 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.
Eur.J.Med.Chem., 288, 2025
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8S4V
 | | Tankyrase 2 in complex with a quinazolin-4-one inhibitor | | Descriptor: | (2~{S})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... | | Authors: | Bosetti, C, Lehtio, L. | | Deposit date: | 2024-02-22 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.
Eur.J.Med.Chem., 288, 2025
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8S4W
 | | Tankyrase 2 in complex with a quinazolin-4-one inhibitor | | Descriptor: | (2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... | | Authors: | Bosetti, C, Lehtio, L. | | Deposit date: | 2024-02-22 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.
Eur.J.Med.Chem., 288, 2025
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8S4X
 | | Tankyrase 2 in complex with a quinazolin-4-one inhibitor | | Descriptor: | 8-[bis(oxidanyl)amino]-2-(4-~{tert}-butylphenyl)-3~{H}-quinazolin-4-one, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... | | Authors: | Bosetti, C, Lehtio, L. | | Deposit date: | 2024-02-22 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.
Eur.J.Med.Chem., 288, 2025
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