9GRT
| Crystal structure of HRP-2 PWWP domain in complex with compound 29 | Descriptor: | 4-bromo-1H-pyrazole, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | Deposit date: | 2024-09-12 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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9G91
| Crystal structure of HRP-2 PWWP domain in complex with compound 43 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | Authors: | Vantieghem, T, Osipov, E.M, Strelkov, S.V. | Deposit date: | 2024-07-24 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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9G96
| Crystal structure of HRP-2 PWWP domain in complex with compound 42 | Descriptor: | 1,2-ETHANEDIOL, 4-[[(5-bromanylpyridin-3-yl)methylamino]methyl]aniline, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E.M, Strelkov, S.V. | Deposit date: | 2024-07-24 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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9G94
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9GRU
| Crystal structure of HRP-2 PWWP domain in complex with compound 30 | Descriptor: | 4-IODOPYRAZOLE, Hepatoma-derived growth factor-related protein 2, SULFATE ION | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | Deposit date: | 2024-09-12 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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9GRS
| Crystal structure of HRP-2 PWWP domain in complex with compound 8 | Descriptor: | 1-bromanyl-4-methylsulfonyl-benzene, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | Deposit date: | 2024-09-12 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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9GRV
| Crystal structure of HRP-2 PWWP domain in complex with compound 37 | Descriptor: | 5-bromanylpyrimidine, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | Deposit date: | 2024-09-12 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HG4
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1696844792 | Descriptor: | 1,2-ETHANEDIOL, 1-(diphenylmethyl)azetidin-3-ol, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HG0
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z46169212 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N-(4-acetylphenyl)-2-(pyrrolidin-1-yl)acetamide, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGH
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z26823525 | Descriptor: | (2S)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)oxolane-2-carboxamide, 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGZ
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1509882419 | Descriptor: | 1,2-ETHANEDIOL, 1-(propan-2-yl)-1H-imidazole-4-sulfonamide, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGK
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z31721798 | Descriptor: | 1,2-ETHANEDIOL, 3-cyclohexyl-1-(morpholin-4-yl)propan-1-one, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HH4
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1139246057 | Descriptor: | (3R)-N-methyl-1-(pyridazin-3-yl)piperidin-3-amine, 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HHO
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z235361315 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HHI
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z805551440 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HG5
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z2142244288 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N-ethyl-2-fluoro-4-(methylsulfonyl)aniline, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGI
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z57475068 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N~1~,N~1~,N~4~,N~4~-tetramethylpiperazine-1,4-dicarboxamide, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HG1
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1079512010 | Descriptor: | 1,2-ETHANEDIOL, 6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGX
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1362754425 | Descriptor: | (2R)-1-(2-methyl-1H-imidazol-1-yl)propan-2-ol, 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HHE
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1203252645 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N-methyl-N-(pyridin-3-yl)acetamide, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGA
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1980894300 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGG
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z422396686 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGW
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1407673036 | Descriptor: | (2R)-2-phenylpropane-1-sulfonamide, 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HGV
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z103740620 | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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7HHC
| PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z31432964 | Descriptor: | (4-methylpiperazin-1-yl)[(2R)-oxolan-2-yl]methanone, 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, ... | Authors: | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | Deposit date: | 2024-08-29 | Release date: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family. Eur.J.Med.Chem., 280, 2024
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