8Z35
 
 | | Crystal Structure of HIF-PHD2 in complex with compound 7 (DS44470011) | | Descriptor: | 2-[[6-methyl-5-oxidanyl-2-[(4-phenylphenyl)methyl]pyrimidin-4-yl]carbonylamino]ethanoic acid, CHLORIDE ION, Egl nine homolog 1, ... | | Authors: | Ito, S, Baba, D, Fukuda, T, Tanaka, N. | | Deposit date: | 2024-04-14 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia.
Bioorg.Med.Chem.Lett., 108, 2024
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8Z32
 | | Crystal Structure of HIF-PHD2 in complex with compound 3 | | Descriptor: | 2-[[6-[(4-fluorophenyl)methyl]-2-methyl-5-oxidanyl-pyrimidin-4-yl]carbonylamino]ethanoic acid, Egl nine homolog 1, FE (II) ION | | Authors: | Ito, S, Baba, D, Fukuda, T, Tanaka, N. | | Deposit date: | 2024-04-14 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia.
Bioorg.Med.Chem.Lett., 108, 2024
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8Z31
 | | Crystal Structure of HIF-PHD2 in complex with compound 1 | | Descriptor: | 2-[(2,6-dimethyl-5-oxidanyl-pyrimidin-4-yl)carbonylamino]ethanoic acid, CHLORIDE ION, Egl nine homolog 1, ... | | Authors: | Ito, S, Baba, D, Fukuda, T, Tanaka, N. | | Deposit date: | 2024-04-14 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia.
Bioorg.Med.Chem.Lett., 108, 2024
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8Z33
 | | Crystal Structure of HIF-PHD2 in complex with compound 4 | | Descriptor: | 2-[[6-[2-(4-fluorophenyl)ethyl]-2-methyl-5-oxidanyl-pyrimidin-4-yl]carbonylamino]ethanoic acid, Egl nine homolog 1, FE (II) ION, ... | | Authors: | Ito, S, Baba, D, Fukuda, T, Tanaka, N. | | Deposit date: | 2024-04-14 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia.
Bioorg.Med.Chem.Lett., 108, 2024
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