PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group.
Descriptor:	Cathepsin K, N-benzyl-3-(2-cyano-6-propylpyrimidin-4-yl)-N-[2-(dimethylamino)ethyl]-5-(trifluoromethyl)benzamide, SULFATE ION
Authors:	Fradera, X, van Zeeland, M, Uitdehaag, J.C.M.
Deposit date:	2010-07-21
Release date:	2010-10-06
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG. Bioorg.Med.Chem.Lett., 20, 2010

Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG
Descriptor:	3-{2-[(E)-iminomethyl]-6-propylpyrimidin-4-yl}-N,N-dimethyl-5-(trifluoromethyl)benzamide, Cathepsin K
Authors:	Fradera, X, van Zeeland, M, Uitdehaag, J.C.M.
Deposit date:	2010-07-20
Release date:	2011-03-30
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG. Bioorg.Med.Chem.Lett., 20, 2010