9NNI
 
 | | Crystal structure of CYP46A1 with cyclopropyl[(4M)-4-(1,3-oxazol-5-yl)-6-(trifluoromethyl)-1H-indol-1-yl]methanone (compound 2b) | | Descriptor: | 1,2-ETHANEDIOL, Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Yano, J, Skene, R.J. | | Deposit date: | 2025-03-05 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.
Bioorg.Med.Chem., 128, 2025
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9NNE
 | | Crystal structure of CYP46A1 with (morpholin-4-yl)[(4R,8M)-8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone (compound 2h) | | Descriptor: | (morpholin-4-yl)[(4R,8M)-8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone, Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Yano, J, Skene, R.J. | | Deposit date: | 2025-03-05 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.
Bioorg.Med.Chem., 128, 2025
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9NNA
 | | Crystal structure of CYP46A1 with [(1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl][(4R,8M)-8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone (compound 3k) | | Descriptor: | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, [(1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl][(4R,8M)-8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone | | Authors: | Yano, J, Skene, R.J. | | Deposit date: | 2025-03-05 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.
Bioorg.Med.Chem., 128, 2025
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