9NNM
 
 | | Crystal structure of CYP46A1 with 3-chloro-N-[(3M)-3-(1,3-oxazol-5-yl)-5-(trifluoromethyl)phenyl]benzamide (compound 3f) | | Descriptor: | 3-chloro-N-[(3M)-3-(1,3-oxazol-5-yl)-5-(trifluoromethyl)phenyl]benzamide, Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Yano, J, Skene, R.J. | | Deposit date: | 2025-03-05 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors.
Bioorg.Med.Chem., 124, 2025
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9NNJ
 | | Crystal structure of CYP46A1 with 3-chloro-N-[(3M)-3-(1,3-oxazol-5-yl)phenyl]-N-(propan-2-yl)benzene-1-sulfonamide (compound 2) | | Descriptor: | 1,2-ETHANEDIOL, 3-chloro-N-[(3M)-3-(1,3-oxazol-5-yl)phenyl]-N-(propan-2-yl)benzene-1-sulfonamide, Cholesterol 24-hydroxylase, ... | | Authors: | Yano, J, Skene, R.J. | | Deposit date: | 2025-03-05 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors.
Bioorg.Med.Chem., 124, 2025
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9NNO
 | | Crystal structure of CYP46A1 with N-[6-(1,3-oxazol-5-yl)-4-(trifluoromethyl)pyridin-2-yl]cyclopropanecarboxamide (compound 4l) | | Descriptor: | 1,2-ETHANEDIOL, Cholesterol 24-hydroxylase, N-[6-(1,3-oxazol-5-yl)-4-(trifluoromethyl)pyridin-2-yl]cyclopropanecarboxamide, ... | | Authors: | Yano, J, Skene, R.J. | | Deposit date: | 2025-03-05 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors.
Bioorg.Med.Chem., 124, 2025
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