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PDB: 1 results

The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.
Descriptor:	(4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one, Poly [ADP-ribose] polymerase 1, processed C-terminus
Authors:	Marcotte, D.J.
Deposit date:	2023-09-11
Release date:	2024-03-27
Method:	X-RAY DIFFRACTION (3.02 Å)
Cite:	Discovery of Potent Isoindolinone Inhibitors That Target an Active Conformation of PARP1 Using DNA-Encoded Libraries. Chemmedchem, 2024