9GPO
 
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/n | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-17-methyl-11,15-dioxa-1-aza-1lambda5-polona-1,18-distannapentacyclo[15.7.0.01,10.010,10.011,16]eicosane-2,12-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPQ
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12h/p | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-17-methyl-11,18-dioxa-1,17lambda5-diphospha-19lambda5-stannapentacyclo[17.3.1.04,9.04,13.015,20]tricosane-2,10-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPU
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12h/k | | Descriptor: | 3-cyclohexyl-23,24-dimethoxy-17-methyl-11,22-dioxa-5-aza-23lambda5,24lambda5-diphospha-2,23lambda5-diphosphapentacyclo[21.2.1.01,18.05,10.018,23]hexacosa-18,24-diene-4,12-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPP
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/o | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-19-methyl-11,20-dioxa-5-aza-1lambda5-polona-1,19lambda5-dithia-18-azanida-1lambda5-stannapentacyclo[19.2.1.05,10.013,18.018,22]tetracosane-4,12-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPV
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/l | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-19-methyl-11,18-dioxa-1,19lambda5-dithia-5-aza-19lambda5-stannapentacyclo[18.3.1.04,9.013,22.015,21]tetracosane-2,10-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPM
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/i | | Descriptor: | 3-cyclohexyl-17,18-dimethoxy-11,15-dioxa-1,18lambda4-dithia-5-aza-17lambda4-polonapentacyclo[15.4.0.04,9.013,18.018,23]henicosane-2,12-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPN
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 11b/j | | Descriptor: | 3-cyclohexyl-1,19-dimethoxy-11,16-dioxa-19lambda4-polona-1,13-diaza-2lambda5-polonapentacyclo[16.4.0.04,9.013,19.020,25]docosane-2,12-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPX
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12f/l | | Descriptor: | 3-cyclohexyl-17-hydroxy-16,17-dimethoxy-12-methyl-15,18-dioxa-5-aza-1lambda5,17lambda5-diphosphapentacyclo[17.3.1.01,10.05,10.011,19]tricosa-10,19(23)-diene-4,11-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPS
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/p | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-19-methyl-11,20-dioxa-5-aza-1lambda5-polona-1,19lambda5-dithia-18-azanida-1lambda5-stannapentacyclo[19.2.1.05,10.013,18.018,22]tetracosane-4,12-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPT
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/k | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-19-methyl-11,18-dioxa-1,19lambda5-dithia-5-aza-19lambda5-stannapentacyclo[18.3.1.04,9.013,22.015,21]tetracosane-2,10-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPW
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12f/j | | Descriptor: | 2-cyclohexyl-18,19-dimethoxy-13-methyl-11,17-dioxa-4-aza-1lambda5,18lambda5-diphospha-1,15-distannatetracyclo[13.4.0.04,9.016,20]nonadecane-3,10-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPR
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12h/m | | Descriptor: | 3-cyclohexyl-19,20-dimethoxy-17-methyl-11,15-dioxa-19lambda4-thia-5-aza-18-stannapentacyclo[15.7.0.01,10.010,10.018,23]tetracosa-13,20-diene-4,12-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPY
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12g/j | | Descriptor: | 1,2-ETHANEDIOL, 2-cyclohexyl-18,19-dimethoxy-13-methyl-11,17-dioxa-4-aza-1lambda5,18lambda5-diphospha-1,15-distannatetracyclo[13.4.0.04,9.016,20]nonadecane-3,10-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPL
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 11c/i | | Descriptor: | 2-cyclohexyl-1,19-dimethoxy-11,18-dioxa-1lambda5,19lambda5-diphospha-2-stannatetracyclo[15.3.0.01,13.04,9]icosane-3,12-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPK
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12c/j | | Descriptor: | 2-cyclohexyl-1,19-dimethoxy-11,18-dioxa-1lambda5,19lambda5-diphospha-2-stannatetracyclo[18.2.1.01,6.06,10]tricosane-3,12-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Walz, C, Buffa, V, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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9GPZ
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12f/o | | Descriptor: | 3-cyclohexyl-17,18-dimethoxy-13-methyl-17-methylol-15,19-dioxa-1,17lambda5-diphospha-1,11lambda5-distannapentacyclo[15.3.1.04,9.011,13.013,19]heneicosane-2,10-quinone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Buffa, V, Walz, C, Hausch, F. | | Deposit date: | 2024-09-09 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformational Plasticity and Binding Affinity Enhancement Controlled by Linker Derivatization in Macrocycles.
Angew.Chem.Int.Ed.Engl., 2025
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