3O1K
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![BU of 3o1k by Molmil](/molmil-images/mine/3o1k) | Crystal structure of putative dihydroneopterin aldolase (FolB) from Vibrio cholerae O1 biovar El Tor str. N16961 | Descriptor: | 1,2-ETHANEDIOL, Dihydroneopterin aldolase FolB, putative | Authors: | Nocek, B, Zhou, M, Papazisi, L, Anderson, W, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2010-07-21 | Release date: | 2010-09-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of putative dihydroneopterin aldolase (FolB) from Vibrio cholerae O1 biovar El Tor str. N16961 To be Published
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8EVK
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![BU of 8evk by Molmil](/molmil-images/mine/8evk) | Crystal structure of Helicobacter pylori dihydroneopterin aldolase (DHNA) | Descriptor: | 1,2-ETHANEDIOL, Dihydroneopterin aldolase, PTERINE | Authors: | Shaw, G.X, Cherry, S, Tropea, J.E, Ji, X. | Deposit date: | 2022-10-20 | Release date: | 2023-03-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design. Curr Res Struct Biol, 5, 2023
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5F3M
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![BU of 5f3m by Molmil](/molmil-images/mine/5f3m) | Crystal structure of dihydroneopterin aldolase from Bacillus anthracis complexed with L-neopterin at 1.5 Angstroms resolution . | Descriptor: | 1,2-ETHANEDIOL, 7,8-dihydroneopterin aldolase, CHLORIDE ION, ... | Authors: | Maltseva, N, Kim, Y, Shatsman, S, Anderson, W.F, Joachimiak, A, CSGID, Center for Structural Genomics of Infectious Diseases, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2015-12-03 | Release date: | 2015-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.498 Å) | Cite: | Crystal structure of dihydroneopterin aldolase from Bacillus anthracis complexed with L-neopterin at 1.5 Angstroms resolution . To Be Published
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1NBU
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![BU of 1nbu by Molmil](/molmil-images/mine/1nbu) | 7,8-Dihydroneopterin Aldolase Complexed with Product From Mycobacterium Tuberculosis | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, Probable dihydroneopterin aldolase | Authors: | Goulding, C.W, Apostol, M.I, Sawaya, M.R, Phillips, M, Parseghian, A, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-03 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J.Mol.Biol., 349, 2005
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6OJO
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![BU of 6ojo by Molmil](/molmil-images/mine/6ojo) | |
1Z9W
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![BU of 1z9w by Molmil](/molmil-images/mine/1z9w) | Tetrameric structure of apo-7,8-Dihydroneopterin Aldolase from Mycobacterium tuberculosis | Descriptor: | Dihydroneopterin aldolase | Authors: | Goulding, C.W, Apostol, M.I, Sawaya, M.R, Philips, M, Parseghian, A, Eisenberg, D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2005-04-05 | Release date: | 2005-04-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J.Mol.Biol., 349, 2005
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3R2E
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![BU of 3r2e by Molmil](/molmil-images/mine/3r2e) | Dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase from Yersinia pestis. | Descriptor: | Dihydroneopterin aldolase | Authors: | Osipiuk, J, Maltseva, N, Makowska-Grzyska, M, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2011-03-14 | Release date: | 2011-03-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase from Yersinia pestis To be Published
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8SU7
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![BU of 8su7 by Molmil](/molmil-images/mine/8su7) | Crystal structure of Bacillus anthracis dihydroneopterin aldolase | Descriptor: | 1,2-ETHANEDIOL, 7,8-dihydroneopterin aldolase | Authors: | Shaw, G.X, Li, Y, Yan, H, Ji, X. | Deposit date: | 2023-05-11 | Release date: | 2023-05-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of Bacillus anthracis dihydroneopterin aldolase To be published
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8SV5
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![BU of 8sv5 by Molmil](/molmil-images/mine/8sv5) | Crystal structure of Bacillus anthracis dihydroneopterin aldolase in complex with 6-hydroxymethyl-7,8-dihydropterin | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-dihydroneopterin aldolase | Authors: | Shaw, G.X, Li, Y, Yan, H, Ji, X. | Deposit date: | 2023-05-15 | Release date: | 2023-06-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of Bacillus anthracis dihydroneopterin aldolase in complex with 6-hydroxymethyl-7,8-dihydropterin To be published
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3V9O
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![BU of 3v9o by Molmil](/molmil-images/mine/3v9o) | |
4AEY
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![BU of 4aey by Molmil](/molmil-images/mine/4aey) | |
1B9L
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![BU of 1b9l by Molmil](/molmil-images/mine/1b9l) | 7,8-DIHYDRONEOPTERIN TRIPHOSPHATE EPIMERASE | Descriptor: | PROTEIN (EPIMERASE) | Authors: | Ploom, T, Haussmann, C, Hof, P, Steinbacher, S, Bacher, A, Richardson, J, Huber, R. | Deposit date: | 1999-02-11 | Release date: | 2000-02-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of 7,8-dihydroneopterin triphosphate epimerase. Structure Fold.Des., 7, 1999
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1DHN
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![BU of 1dhn by Molmil](/molmil-images/mine/1dhn) | 1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS | Descriptor: | 7,8-DIHYDRONEOPTERIN ALDOLASE | Authors: | Hennig, M, D'Arcy, A, Hampele, I.C, Page, M.G.P, Oefner, C.H, Dale, G. | Deposit date: | 1998-03-31 | Release date: | 1999-04-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Nat.Struct.Biol., 5, 1998
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2DHN
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![BU of 2dhn by Molmil](/molmil-images/mine/2dhn) | COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-DIHYDRONEOPTERIN ALDOLASE | Authors: | Hennig, M, D'Arcy, A, Hampele, I.C, Page, M.G.P, Oefner, C.H, Dale, G. | Deposit date: | 1998-03-31 | Release date: | 1999-04-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Nat.Struct.Biol., 5, 1998
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2NM3
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![BU of 2nm3 by Molmil](/molmil-images/mine/2nm3) | Crystal structure of dihydroneopterin aldolase from S. aureus in complex with (1S,2S)-monapterin at 1.68 angstrom resolution | Descriptor: | ACETATE ION, D-MONAPTERIN, Dihydroneopterin aldolase | Authors: | Blaszczyk, J, Ji, X, Yan, H. | Deposit date: | 2006-10-20 | Release date: | 2007-09-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase. J.Mol.Biol., 368, 2007
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2NM2
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![BU of 2nm2 by Molmil](/molmil-images/mine/2nm2) | |
2O90
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![BU of 2o90 by Molmil](/molmil-images/mine/2o90) | |
1RSD
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![BU of 1rsd by Molmil](/molmil-images/mine/1rsd) | DHNA complex with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamide | Descriptor: | 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-[2-(2-(HYDROXYMETHYL-PHENYLSULFANYL)-BENZYL]-BENZAMIDE, Dihydroneopterin aldolase | Authors: | Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A. | Deposit date: | 2003-12-09 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. J.Med.Chem., 47, 2004
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1RRW
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![BU of 1rrw by Molmil](/molmil-images/mine/1rrw) | DHNA complexed with 9-methylguanine | Descriptor: | 9-METHYLGUANINE, Dihydroneopterin aldolase | Authors: | Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A. | Deposit date: | 2003-12-09 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. J.Med.Chem., 47, 2004
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1RS2
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![BU of 1rs2 by Molmil](/molmil-images/mine/1rs2) | DHNA complex with 8-Amino-1,3-dimethyl-3,7-dihydropurine-2,6-dione | Descriptor: | 8-AMINO-1,3-DIMETHYL-3,7-DIHYDROPURINE-2,6-DIONE, Dihydroneopterin aldolase | Authors: | Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A. | Deposit date: | 2003-12-09 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. J.Med.Chem., 47, 2004
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1RRI
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![BU of 1rri by Molmil](/molmil-images/mine/1rri) | DHNA complex with 3-(5-amino-7-hydroxy-[1,2,3] triazolo [4,5-d]pyrimidin-2-yl)-benzoic acid | Descriptor: | 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-BENZOIC ACID, Dihydroneopterin aldolase | Authors: | Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A. | Deposit date: | 2003-12-08 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization. J.Med.Chem., 47, 2004
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7SU8
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![BU of 7su8 by Molmil](/molmil-images/mine/7su8) | |
7SU6
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![BU of 7su6 by Molmil](/molmil-images/mine/7su6) | DIHYDRONEOPTERIN ALDOLASE (DHNA) Lys98Ala FROM YERSINIA PESTIS CO-CRYSTALLIZED with 7,8-dihydroneopterin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, 7,8-dihydroneopterin aldolase | Authors: | Bourne, C.R. | Deposit date: | 2021-11-16 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | DIHYDRONEOPTERIN ALDOLASE (DHNA) Lys98Ala FROM YERSINIA PESTIS CO-CRYSTALLIZED with 7,8-dihydroneopterin To Be Published
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7SU4
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![BU of 7su4 by Molmil](/molmil-images/mine/7su4) | Dihydroneopterin aldolase (DHNA) Tyr53Phe from Yersinia pestis co-crystallized with 7,8-dihydroneopterin | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, 7,8-dihydroneopterin aldolase, ... | Authors: | Bourne, C.R. | Deposit date: | 2021-11-16 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Dihydroneopterin aldolase (DHNA) Tyr53Phe from Yersinia pestis co-crystallized with 7,8-dihydroneopterin To Be Published
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7SU7
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![BU of 7su7 by Molmil](/molmil-images/mine/7su7) | |