5FRC
 
 | | Structure of urate oxidase prepared by the 'soak-and-freeze' method under 42 bar of oxygen pressure | | Descriptor: | 8-AZAXANTHINE, OXYGEN MOLECULE, SODIUM ION, ... | | Authors: | Lafumat, B, Mueller-Dieckmann, C, Colloc'h, N, Prange, T, Royant, A, van der Linden, P, Carpentier, P. | | Deposit date: | 2015-12-16 | | Release date: | 2016-10-26 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.443 Å) | | Cite: | Gas-Sensitive Biological Crystals Processed in Pressurized Oxygen and Krypton Atmospheres: Deciphering Gas Channels in Proteins Using a Novel `Soak-and-Freeze' Methodology.
J.Appl.Crystallogr., 49, 2016
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1J2G
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4XFP
 | | Crystal Structure of Highly Active Mutant of Bacillus sp. TB-90 Urate Oxidase | | Descriptor: | 8-AZAXANTHINE, CHLORIDE ION, SULFATE ION, ... | | Authors: | Hibi, T, Hayashi, Y, Kawamura, A, Itoh, T. | | Deposit date: | 2014-12-28 | | Release date: | 2016-01-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Glycine Substitution of Surface Proline 287 Involves Entropic Enhancement of Bacillus sp. TB-90 Uricase Activity
To be published
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4FSK
 | | Urate oxidase-azide complex in anaerobic conditions | | Descriptor: | AZIDE ION, SODIUM ION, Uricase | | Authors: | Gabison, L, Colloc'h, N, El Hajji, M, Castro, B, Chiadmi, M, Prange, T. | | Deposit date: | 2012-06-27 | | Release date: | 2013-07-03 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Azide and Cyanide Have Different Inhibition Modes of Urate Oxidase
To be Published
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3L8W
 | | Urate oxidase from aspergillus flavus complexed with xanthin | | Descriptor: | SODIUM ION, Uricase, XANTHINE, ... | | Authors: | Prange, T, Gabison, L, Colloc'h, N, Chiadmi, M. | | Deposit date: | 2010-01-04 | | Release date: | 2010-06-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
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7QAR
 | | Serial crystallography structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-methyl uric acid at room temperature | | Descriptor: | (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, Uricase | | Authors: | Bui, S, Catapano, L, Zielinski, K, Yefanov, O, Murshudov, G.N, Oberthuer, D, Steiner, R.A. | | Deposit date: | 2021-11-17 | | Release date: | 2023-04-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive.
Iucrj, 9, 2022
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3WLV
 | | Thermostable urate oxidase from Bacillus sp. TB-90 | | Descriptor: | 8-AZAXANTHINE, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Hibi, T, Hayashi, Y, Itoh, T. | | Deposit date: | 2013-11-14 | | Release date: | 2014-06-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.747 Å) | | Cite: | Intersubunit salt bridges with a sulfate anion control subunit dissociation and thermal stabilization of Bacillus sp. TB-90 urate oxidase.
Biochemistry, 53, 2014
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6OE8
 | | The crystal structure of hyper-thermostable AgUricase mutant K12C/E286C | | Descriptor: | MALONATE ION, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | | Authors: | Shi, Y, Wang, T, Zhou, X.E, Liu, Q, Jiang, Y, Xu, H.E. | | Deposit date: | 2019-03-27 | | Release date: | 2019-08-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy.
Acta Pharmacol.Sin., 40, 2019
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7A0L
 | | Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole | | Descriptor: | 8-AZAXANTHINE, SODIUM ION, Uricase | | Authors: | McGregor, L, Bui, S, Blakeley, M.P, Steiner, R.A. | | Deposit date: | 2020-08-09 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-01 | | Method: | NEUTRON DIFFRACTION (1.33 Å), X-RAY DIFFRACTION | | Cite: | Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.
Iucrj, 8, 2021
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4MB8
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3GKO
 | | Crystal structure of urate oxydase using surfactant Poloxamer 188 as a New Crystallizing Agent | | Descriptor: | 8-AZAXANTHINE, POTASSIUM ION, Uricase | | Authors: | Delfosse, V, Giffard, M, Sciara, G, Bonnete, F, Mayer, C. | | Deposit date: | 2009-03-11 | | Release date: | 2010-02-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Surfactant Poloxamer 188 as a New Crystallizing Agent for Urate Oxidase
Cryst.Growth Des., 9, 2009
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5AYJ
 | | Hyperthermostable mutant of Bacillus sp. TB-90 Urate Oxidase - R298C | | Descriptor: | 9-METHYL URIC ACID, HEXAETHYLENE GLYCOL, SULFATE ION, ... | | Authors: | Hibi, T, Kume, A, Kawamura, A, Itoh, T, Nishiya, Y. | | Deposit date: | 2015-08-21 | | Release date: | 2016-01-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Hyperstabilization of Tetrameric Bacillus sp. TB-90 Urate Oxidase by Introducing Disulfide Bonds through Structural Plasticity
Biochemistry, 55, 2016
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2PES
 | | Urate Oxidase in complex with tris-dipicolinate Lutetium | | Descriptor: | 8-AZAXANTHINE, LUTETIUM (III) ION, PYRIDINE-2,6-DICARBOXYLIC ACID, ... | | Authors: | Pompidor, G, Vicat, J, Kahn, R. | | Deposit date: | 2007-04-03 | | Release date: | 2008-04-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A dipicolinate lanthanide complex for solving protein structures using anomalous diffraction.
Acta Crystallogr.,Sect.D, 66, 2010
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2FUB
 | | Crystal structure of urate oxidase at 140 MPa | | Descriptor: | 8-AZAXANTHINE, CYSTEINE, Uricase | | Authors: | Colloc'h, N, Girard, E, Fourme, R. | | Deposit date: | 2006-01-26 | | Release date: | 2006-02-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | High pressure macromolecular crystallography: The 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly
Biochim.Biophys.Acta, 1764, 2006
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6RGM
 | | urate oxidase under 130 bar of krypton | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | | Authors: | Prange, T, Colloc'h, N, Carpentier, P. | | Deposit date: | 2019-04-17 | | Release date: | 2020-05-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
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5M98
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1WRR
 | | Urate oxidase from aspergillus flavus complexed with 5-amino 6-nitro uracil | | Descriptor: | 5-AMINO-6-NITROPYRIMIDINE-2,4(1H,3H)-DIONE, Uricase | | Authors: | Retailleau, P, Colloc'h, N, Vivares, D, Bonnete, F, Castro, B, El Hajji, M, Prange, T. | | Deposit date: | 2004-10-27 | | Release date: | 2005-03-22 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site.
Acta Crystallogr.,Sect.D, 61, 2005
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1WS3
 | | Urate oxidase from aspergillus flavus complexed with uracil | | Descriptor: | URACIL, Uricase | | Authors: | Retailleau, P, Colloc'h, N, Vivares, D, Bonnete, F, Castro, B, El Hajji, M, Prange, T. | | Deposit date: | 2004-10-29 | | Release date: | 2005-03-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site.
Acta Crystallogr.,Sect.D, 61, 2005
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2FXL
 | | Urate oxidase from aspergillus flavus complexed with allantoin | | Descriptor: | 1-(2,5-DIOXO-2,5-DIHYDRO-1H-IMIDAZOL-4-YL)UREA, Uricase | | Authors: | Gabison, L, Chiadmi, M, Colloc'h, N, Prange, T. | | Deposit date: | 2006-02-06 | | Release date: | 2006-05-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase.
Febs Lett., 580, 2006
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1R51
 | | URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR 8-AZAXANTHIN | | Descriptor: | 8-AZAXANTHINE, CYSTEINE, Uricase | | Authors: | Prange, T, Retailleau, P, Colloc'h, N. | | Deposit date: | 2003-10-09 | | Release date: | 2004-03-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Acta Crystallogr.,Sect.D, 60, 2004
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1R4S
 | | URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR 9-METHYL URIC ACID | | Descriptor: | 9-METHYL URIC ACID, CYSTEINE, Uricase | | Authors: | Retailleau, P, Colloc'h, N, Prange, T. | | Deposit date: | 2003-10-08 | | Release date: | 2004-03-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Acta Crystallogr.,Sect.D, 60, 2004
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5LL1
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6RGT
 | | Crystal structure of the cofactor-free Aspergillus flavus urate oxidase T57A variant anaerobically complexed with 9-methyl uric acid | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 9-METHYL URIC ACID, ... | | Authors: | Bui, S, Lowden, S.R.J, Steiner, R.A. | | Deposit date: | 2019-04-17 | | Release date: | 2020-05-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of the cofactor-free Aspergillus flavus urate oxidase T57A variant anaerobically complexed with 9-methyl uric acid
To Be Published
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1R4U
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1R56
 | | UNCOMPLEXED URATE OXIDASE FROM ASPERGILLUS FLAVUS | | Descriptor: | DI(HYDROXYETHYL)ETHER, Uricase | | Authors: | Retailleau, P, Colloc'h, N, Prange, T. | | Deposit date: | 2003-10-09 | | Release date: | 2004-03-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Acta Crystallogr.,Sect.D, 60, 2004
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