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4CIK	plasminogen kringle 1 in complex with inhibitor Descriptor: 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one, PLASMINOGEN Authors: Xue, Y, Johansson, C, Cheng, L, Pettersen, D, Gustafsson, D. Deposit date: 2013-12-10 Release date: 2014-06-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction. Acs Med.Chem.Lett., 5, 2014
7TNG	Kringle domain of human Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1 Authors: Guarino, S.R, Di Bello, A, Palamini, M, Forneris, F. Deposit date: 2022-01-21 Release date: 2022-05-11 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1) Acta Crystallogr.,Sect.F, 78, 2022
6RX7	Structure of the KIV type 2 (KIV-2) domain of lipoprotein (a) Descriptor: Apolipoprotein(a), GLYCEROL, SULFATE ION Authors: Santonastaso, A, Maggi, M, Scotti, C. Deposit date: 2019-06-07 Release date: 2020-07-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.63 Å) Cite: High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site. J.Lipid Res., 61, 2020
1URK	SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR Descriptor: PLASMINOGEN ACTIVATOR, alpha-L-fucopyranose Authors: Hansen, A.P, Petros, A.M, Meadows, R.P, Nettesheim, D.G, Mazar, A.P, Olejniczak, E.T, Xu, R.X, Pederson, T.M, Henkin, J, Fesik, S.W. Deposit date: 1994-01-10 Release date: 1995-05-08 Last modified: 2020-07-29 Method: SOLUTION NMR Cite: Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator. Biochemistry, 33, 1994
2L0S	Solution Structure of Human Plasminogen Kringle 3 Descriptor: Plasminogen Authors: Christen, M.T, Frank, P, Schaller, J, Llinas, M. Deposit date: 2010-07-15 Release date: 2010-08-04 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape. Biochemistry, 49, 2010
1TPK	CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR Authors: De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A. Deposit date: 1991-09-24 Release date: 1992-07-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. Biochemistry, 31, 1992
2KNF	Solution structure and functional characterization of human plasminogen kringle 5 Descriptor: Plasminogen Authors: Battistel, M.D, Grishaev, A, An, S.A, Castellino, F.J, Llinas, M. Deposit date: 2009-08-21 Release date: 2009-10-27 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Solution structure and functional characterization of human plasminogen kringle 5. Biochemistry, 48, 2009
3KIV	RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A) Descriptor: 6-AMINOHEXANOIC ACID, APOLIPOPROTEIN Authors: Mochalkin, I, Tulinsky, A, Scanu, A. Deposit date: 1998-09-08 Release date: 1999-05-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance. Biochemistry, 38, 1999
4KIV	RECOMBINANT KRINGLE IV-10/W72R MUTANT OF HUMAN APOLIPOPROTEIN(A) Descriptor: APOLIPOPROTEIN Authors: Mochalkin, I, Tulinsky, A, Scanu, A. Deposit date: 1998-08-26 Release date: 1999-05-18 Last modified: 2018-03-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance. Biochemistry, 38, 1999
1CEB	THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID) Descriptor: PLASMINOGEN, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1995-12-03 Release date: 1996-04-03 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Biochemistry, 35, 1996
1B2I	KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX Descriptor: PROTEIN (PLASMINOGEN), TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID Authors: Marti, D.N, Schaller, J, Llinas, M. Deposit date: 1999-09-24 Release date: 1999-11-19 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains. Biochemistry, 38, 1999
1CEA	THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID) Descriptor: 6-AMINOHEXANOIC ACID, PLASMINOGEN Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1995-12-03 Release date: 1996-04-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Biochemistry, 35, 1996
5Z55	NMR Solution Structure of the Kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1) Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1 Authors: Ma, X, Hu, K.F. Deposit date: 2018-01-17 Release date: 2018-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1). Biomol NMR Assign, 12, 2018
8TCE	Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3353871 Descriptor: (2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic acid, Apolipoprotein(a) Authors: Hendle, J, Weichert, K, Sauder, J.M. Deposit date: 2023-06-30 Release date: 2024-05-08 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629, 2024
6BA5	Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ... Authors: Park, H, Rader, C. Deposit date: 2017-10-12 Release date: 2018-06-13 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8V9B	Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732 Descriptor: (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ... Authors: Hendle, J, Weichert, K, Sauder, J.M. Deposit date: 2023-12-07 Release date: 2024-05-08 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.19 Å) Cite: Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629, 2024
8V8Z	Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3473329 Descriptor: Apolipoprotein(a), muvalaplin Authors: Hendle, J, Weichert, K, Sauder, J.M. Deposit date: 2023-12-06 Release date: 2024-05-08 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629, 2024
6BAN	Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain Authors: Park, H, Rader, C. Deposit date: 2017-10-14 Release date: 2018-06-13 Last modified: 2019-12-04 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1PMK	KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES Descriptor: PLASMINOGEN KRINGLE 4 Authors: Padmanabhan, K, Tulinsky, A. Deposit date: 1994-04-25 Release date: 1994-06-22 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Kringle-kringle interactions in multimer kringle structures. Protein Sci., 3, 1994
1PK4	CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN PLASMINOGEN KRINGLE 4 REFINED AT 1.9-ANGSTROMS RESOLUTION Descriptor: PLASMINOGEN KRINGLE 4, SULFATE ION Authors: Tulinsky, A, Mulichak, A.M. Deposit date: 1991-07-18 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution. Biochemistry, 30, 1991
1PK2	SOLUTION STRUCTURE OF THE TISSUE-TYPE PLASMINOGEN ACTIVATOR KRINGLE 2 DOMAIN COMPLEXED TO 6-AMINOHEXANOIC ACID AN ANTIFIBRINOLYTIC DRUG Descriptor: 6-AMINOHEXANOIC ACID, TISSUE-TYPE PLASMINOGEN ACTIVATOR Authors: Llinas, M, Byeon, I.-J.L. Deposit date: 1991-09-16 Release date: 1994-01-31 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug. J.Mol.Biol., 222, 1991
1PKR	THE STRUCTURE OF RECOMBINANT PLASMINOGEN KRINGLE 1 AND THE FIBRIN BINDING SITE Descriptor: CHLORIDE ION, PLASMINOGEN Authors: Wu, T.-P, Tulinsky, A. Deposit date: 1993-08-03 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The structure of recombinant plasminogen kringle 1 and the fibrin binding site. Blood Coagulation Fibrinolysis, 5, 1994
1PML	KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR KRINGLE 2 Authors: Padmanabhan, K, Tulinsky, A. Deposit date: 1994-04-25 Release date: 1994-06-22 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Kringle-kringle interactions in multimer kringle structures. Protein Sci., 3, 1994
2PK4	THE REFINED STRUCTURE OF THE EPSILON-AMINOCAPROIC ACID COMPLEX OF HUMAN PLASMINOGEN KRINGLE Descriptor: 6-AMINOHEXANOIC ACID, HUMAN PLASMINOGEN KRINGLE 4 Authors: Tulinsky, A, Wu, T.-P. Deposit date: 1991-07-18 Release date: 1993-10-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4. Biochemistry, 30, 1991
5HPG	STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN Descriptor: PLASMINOGEN Authors: Tulinsky, A, Mochalkin, I, Castellino, F.J. Deposit date: 1997-09-19 Release date: 1998-03-25 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. Biochemistry, 37, 1998

 

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