PDB: 46200 resultsInfo pagesStatus searchChemie searchBIRD

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2ZOQ	Structural dissection of human mitogen-activated kinase ERK1 Descriptor: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Mitogen-activated protein kinase 3, SODIUM ION, ... Authors: Kinoshita, T, Tada, T, Nakae, S, Yoshida, I. Deposit date: 2008-06-01 Release date: 2009-04-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Crystal structure of human mono-phosphorylated ERK1 at Tyr204 Biochem.Biophys.Res.Commun., 377, 2008
7UCK	80S translation initiation complex with ac4c(-1) mRNA and Harringtonine Descriptor: 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... Authors: Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. Deposit date: 2022-03-16 Release date: 2022-06-01 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
6YLG	Rix1-Rea1 pre-60S particle - 60S core, body 1 (rigid body refinement) Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Kater, L, Beckmann, R. Deposit date: 2020-04-07 Release date: 2020-07-29 Last modified: 2020-09-02 Method: ELECTRON MICROSCOPY (3 Å) Cite: Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Mol.Cell, 79, 2020
8H6T	Complex structure of CDK2/Cyclin E1 and a potent, selective small molecule inhibitor Descriptor: (1R,3S)-3-{3-[(pyridin-2-yl)amino]-1H-pyrazol-5-yl}cyclopentyl propan-2-ylcarbamate, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 Authors: Ren, X. Deposit date: 2022-10-18 Release date: 2023-02-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. Acs Med.Chem.Lett., 14, 2023
8H6P	Complex structure of CDK2/Cyclin E1 and a potent, selective macrocyclic inhibitor Descriptor: (7S,10R)-11-oxa-2,4,5,13,17,23-hexaazatetracyclo[17.3.1.1~3,6~.1~7,10~]pentacosa-1(23),3(25),5,19,21-pentaene-12,18-dione, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 Authors: Ren, X. Deposit date: 2022-10-18 Release date: 2023-02-22 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. Acs Med.Chem.Lett., 14, 2023
4ABZ	TetR(D) in Complex with Tigecycline and Magnesium, co-crystallized Descriptor: CHLORIDE ION, MAGNESIUM ION, TIGECYCLINE, ... Authors: Volkers, G, Hinrichs, W. Deposit date: 2011-12-12 Release date: 2012-12-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.886 Å) Cite: TetR(D) in Complex with Tigecycline and Magnesium To be Published
7TOR	Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... Authors: Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. Deposit date: 2022-01-24 Release date: 2022-05-25 Last modified: 2022-06-01 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
5UQ1	Crystal structure of human Cdk2-Spy1 complex Descriptor: Cyclin-dependent kinase 2, Speedy protein A Authors: McGrath, D.A, Tripathi, S.M, Rubin, S.M. Deposit date: 2017-02-06 Release date: 2017-07-05 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (3.201 Å) Cite: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
7UCJ	Mammalian 80S translation initiation complex with mRNA and Harringtonine Descriptor: 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... Authors: Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. Deposit date: 2022-03-16 Release date: 2022-06-01 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
7TOQ	Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... Authors: Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. Deposit date: 2022-01-24 Release date: 2022-05-25 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
3J9Y	Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Arenz, S, Nguyen, F, Beckmann, R, Wilson, D.N. Deposit date: 2015-03-23 Release date: 2015-04-15 Last modified: 2022-12-21 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9- angstrom resolution. Proc.Natl.Acad.Sci.USA, 112, 2015
3JBU	Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Zhang, J, Pan, X.J, Yan, K.G, Sun, S, Gao, N, Sui, S.F. Deposit date: 2015-10-16 Release date: 2016-01-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Mechanisms of ribosome stalling by SecM at multiple elongation steps Elife, 4, 2015
4B1R	Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline Descriptor: CHLORIDE ION, ISO-7-CHLORTETRACYCLINE, TETRACYCLINE REPRESSOR PROTEIN CLASS D Authors: Eltschkner, S, Palm, G.J, Schneider, J, Hinrichs, W. Deposit date: 2012-07-12 Release date: 2013-07-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Tetracycline Repressor Class D Mutant H100A in Complex with Iso-7-Chlortetracycline To be Published
6I0Y	TnaC-stalled ribosome complex with the titin I27 domain folding close to the ribosomal exit tunnel Descriptor: 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... Authors: Su, T, Kudva, R, von Heijne, G, Beckmann, R. Deposit date: 2018-10-26 Release date: 2018-12-05 Last modified: 2019-01-23 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Folding pathway of an Ig domain is conserved on and off the ribosome. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7UXK	Structure of CDK2 in complex with FP24322, a Helicon Polypeptide Descriptor: 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, FP24322, ... Authors: Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. Deposit date: 2022-05-05 Release date: 2022-12-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.63 Å) Cite: De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7UXI	Structure of CDK2 in complex with FP19711, a Helicon Polypeptide Descriptor: AMINO GROUP, Cyclin-dependent kinase 2, FP19711, ... Authors: Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. Deposit date: 2022-05-05 Release date: 2022-12-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.07 Å) Cite: De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7NWG	Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S. Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ... Authors: Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. Deposit date: 2021-03-16 Release date: 2021-07-07 Last modified: 2023-01-11 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA. Nucleic Acids Res., 49, 2021
7NWI	Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S Descriptor: 18S ribosomal RNA, 28S ribosomal RNA+BlaS, 40S ribosomal protein S11, ... Authors: Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. Deposit date: 2021-03-16 Release date: 2021-07-07 Last modified: 2023-01-11 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA. Nucleic Acids Res., 49, 2021
3JCE	Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4) Descriptor: 16S ribosomal RNA, 23 ribosomal RNA, 30S ribosomal protein S10, ... Authors: Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y. Deposit date: 2015-12-01 Release date: 2016-01-13 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome Nat. Struct. Mol. Biol., 23, 2016
4TYH	Ternary complex of P38 and MK2 with a P38 inhibitor Descriptor: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide Authors: Cumming, J.G, Debreczeni, J.E, Edfeldt, F, Evertsson, F, Harrison, M, Holdgate, G, James, M, Lamont, S, Oldham, K, Sullivan, J.E, Wells, S. Deposit date: 2014-07-08 Release date: 2015-07-22 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors To Be Published
7BY2	Toxin-antitoxin complex from Klebsiella pneumoniae Descriptor: CopG family transcriptional regulator, Ribonuclease VapC Authors: Kang, S.M. Deposit date: 2020-04-21 Release date: 2021-04-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Toxin-antitoxin complex from Klebsiella pneumoniae To Be Published
7BY3	Toxin-antitoxin complex from klebsiella pneumoniae Descriptor: CopG family transcriptional regulator, Ribonuclease VapC, SULFATE ION Authors: Kang, S.M. Deposit date: 2020-04-21 Release date: 2021-04-28 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Toxin-antitoxin complex from klebsiella pneumoniae To Be Published
7MDZ	80S rabbit ribosome stalled with benzamide-CHX Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S21, ... Authors: Koga, Y, Hoang, E.M, Park, Y, Keszei, A.F.A, Murray, J, Shao, S, Liau, B.B. Deposit date: 2021-04-06 Release date: 2021-09-01 Last modified: 2021-09-15 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. J.Am.Chem.Soc., 143, 2021
3J9Z	Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J. Deposit date: 2015-03-27 Release date: 2015-07-01 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G. Sci Adv, 1, 2015
3JCD	Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4) Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y. Deposit date: 2015-12-01 Release date: 2016-01-13 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome Nat. Struct. Mol. Biol., 23, 2016

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