1YUC
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![BU of 1yuc by Molmil](/molmil-images/mine/1yuc) | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP | Descriptor: | GLYCEROL, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, Nuclear receptor 0B2, ... | Authors: | Ortlund, E.A, Yoonkwang, L, Solomon, I.H, Hager, J.M, Safi, R, Choi, Y, Guan, Z, Tripathy, A, Raetz, C.R.H, McDonnell, D.P, Moore, D.D, Redinbo, M.R. | Deposit date: | 2005-02-13 | Release date: | 2005-03-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP Nat.Struct.Mol.Biol., 12, 2005
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6SEG
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![BU of 6seg by Molmil](/molmil-images/mine/6seg) | Class1: CENP-A nucleosome in complex with CENP-C central region | Descriptor: | DNA (145-MER), Histone H2A type 2-A, Histone H2B type 1-C/E/F/G/I, ... | Authors: | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | Deposit date: | 2019-07-30 | Release date: | 2019-08-14 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
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5JJE
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![BU of 5jje by Molmil](/molmil-images/mine/5jje) | Structure of the SRII/HtrII Complex in I212121 space group ("U" shape) | Descriptor: | EICOSANE, RETINAL, Sensory rhodopsin II transducer, ... | Authors: | Ishchenko, A, Round, E, Borshchevskiy, V, Grudinin, S, Gushchin, I, Klare, J, Remeeva, A, Polovinkin, V, Utrobin, P, Balandin, T, Engelhard, M, Bueldt, G, Gordeliy, V. | Deposit date: | 2016-04-23 | Release date: | 2017-02-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | New Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex. Sci Rep, 7, 2017
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4GC7
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![BU of 4gc7 by Molmil](/molmil-images/mine/4gc7) | Crystal structure of Dpo4 in complex with S-MC-dADP opposite dT | Descriptor: | CALCIUM ION, DNA (5'-D(*G*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*C)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... | Authors: | Eoff, R.L, Ketkar, A, Banerjee, S, Zafar, M.K. | Deposit date: | 2012-07-29 | Release date: | 2012-10-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry, 51, 2012
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2WEI
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![BU of 2wei by Molmil](/molmil-images/mine/2wei) | Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1 | Descriptor: | 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALMODULIN-DOMAIN PROTEIN KINASE 1, PUTATIVE | Authors: | Roos, A.K, King, O, Chaikuad, A, Zhang, C, Shokat, K.M, Wernimont, A.K, Artz, J.D, Lin, L, MacKenzie, F.I, Finerty, P.J, Vedadi, M, Schapira, M, Indarte, M, Kozieradzki, I, Pike, A.C.W, Fedorov, O, Doyle, D, Muniz, J, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, von Delft, F, Heightman, T, Hui, R. | Deposit date: | 2009-03-31 | Release date: | 2009-04-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Cryptosporidium Parvum Kinome. Bmc Genomics, 12, 2011
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1YQT
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![BU of 1yqt by Molmil](/molmil-images/mine/1yqt) | RNase-L Inhibitor | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RNase l inhibitor | Authors: | Karcher, A, Buttner, K, Martens, B, Jansen, R.P, Hopfner, K.P. | Deposit date: | 2005-02-02 | Release date: | 2005-04-19 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly. Structure, 13, 2005
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1X3E
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![BU of 1x3e by Molmil](/molmil-images/mine/1x3e) | Crystal structure of the single-stranded DNA-binding protein from Mycobacterium smegmatis | Descriptor: | CADMIUM ION, Single-strand binding protein | Authors: | Saikrishnan, K, Manjunath, G.P, Singh, P, Jeyakanthan, J, Dauter, Z, Sekar, K, Muniyappa, K, Vijayan, M. | Deposit date: | 2005-05-04 | Release date: | 2005-08-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association. Acta Crystallogr.,Sect.D, 61, 2005
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2W6E
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![BU of 2w6e by Molmil](/molmil-images/mine/2w6e) | Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration:hydration state 1. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP SYNTHASE SUBUNIT ALPHA HEART ISOFORM, MITOCHONDRIAL, ... | Authors: | Sanchez-Weatherby, J, Felisaz, F, Gobbo, A, Huet, J, Ravelli, R.B.G, Bowler, M.W, Cipriani, F. | Deposit date: | 2008-12-18 | Release date: | 2009-10-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (6.5 Å) | Cite: | Improving Diffraction by Humidity Control: A Novel Device Compatible with X-Ray Beamlines. Acta Crystallogr.,Sect.D, 65, 2009
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2WH0
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![BU of 2wh0 by Molmil](/molmil-images/mine/2wh0) | Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon | Descriptor: | 14-3-3 PROTEIN ZETA/DELTA, CALCIUM ION, PROTEIN KINASE C EPSILON TYPE, ... | Authors: | Kostelecky, B, Saurin, A.T, Purkiss, A, Parker, P.J, McDonald, N.Q. | Deposit date: | 2009-04-28 | Release date: | 2009-08-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Recognition of an Intra-Chain Tandem 14-3-3 Binding Site within Pkc Epsilon. Embo Rep., 10, 2009
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3Q8C
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![BU of 3q8c by Molmil](/molmil-images/mine/3q8c) | Crystal structure of Protective Antigen W346F (pH 5.5) | Descriptor: | CALCIUM ION, Protective antigen | Authors: | Lovell, S, Battaile, K.P, Rajapaksha, M, Janowiak, B.E, Andra, K.K, Bann, J.G. | Deposit date: | 2011-01-06 | Release date: | 2012-02-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci., 21, 2012
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5H1I
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![BU of 5h1i by Molmil](/molmil-images/mine/5h1i) | NMR structure of TIBA, a chimera of SFTI | Descriptor: | Bradykinin-trypsin inhibitor secondary loop chimera | Authors: | Xiao, T, Tam, J.P. | Deposit date: | 2016-10-10 | Release date: | 2017-04-19 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor. J. Med. Chem., 60, 2017
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5GIW
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![BU of 5giw by Molmil](/molmil-images/mine/5giw) | Solution NMR structure of Humanin containing a D-isomerized serine residue | Descriptor: | Humanin | Authors: | Furuita, K, Sugiki, T, Alsanousi, N, Fujiwara, T, Kojima, C. | Deposit date: | 2016-06-25 | Release date: | 2016-07-20 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution NMR structure and inhibitory effect against amyloid-beta fibrillation of Humanin containing a d-isomerized serine residue Biochem.Biophys.Res.Commun., 477, 2016
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5H3M
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![BU of 5h3m by Molmil](/molmil-images/mine/5h3m) | |
3SC0
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![BU of 3sc0 by Molmil](/molmil-images/mine/3sc0) | Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with MethylCobalamin | Descriptor: | CO-METHYLCOBALAMIN, Methylmalonic aciduria and homocystinuria type C protein | Authors: | Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R. | Deposit date: | 2011-06-06 | Release date: | 2011-06-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of multifunctionality in a vitamin B12-processing enzyme. J.Biol.Chem., 286, 2011
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3LA3
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![BU of 3la3 by Molmil](/molmil-images/mine/3la3) | Crystal structure of NtcA in complex with 2,2-difluoropentanedioic acid | Descriptor: | 2,2-difluoropentanedioic acid, Global nitrogen regulator | Authors: | Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z. | Deposit date: | 2010-01-06 | Release date: | 2010-07-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc.Natl.Acad.Sci.USA, 107, 2010
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2X9C
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![BU of 2x9c by Molmil](/molmil-images/mine/2x9c) | Crystal structure of a soluble PrgI mutant from Salmonella Typhimurium | Descriptor: | PROTEIN PRGI | Authors: | Poyraz, O, Schmidt, H, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinsky, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M. | Deposit date: | 2010-03-15 | Release date: | 2010-06-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Protein Refolding is Required for Assembly of the Type Three Secretion Needle Nat.Struct.Mol.Biol., 17, 2010
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3SBZ
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![BU of 3sbz by Molmil](/molmil-images/mine/3sbz) | Crystal Structure of Apo-MMACHC (1-244), a human B12 processing enzyme | Descriptor: | GLYCEROL, MALONATE ION, Methylmalonic aciduria and homocystinuria type C protein | Authors: | Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R. | Deposit date: | 2011-06-06 | Release date: | 2011-06-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of multifunctionality in a vitamin B12-processing enzyme. J.Biol.Chem., 286, 2011
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5KPX
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![BU of 5kpx by Molmil](/molmil-images/mine/5kpx) | Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-07-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife, 5, 2016
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2WZY
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![BU of 2wzy by Molmil](/molmil-images/mine/2wzy) | Crystal structure of A-AChBP in complex with 13-desmethyl spirolide C | Descriptor: | 13-DESMETHYL SPIROLIDE C, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Bourne, Y, Radic, Z, Araoz, R, Talley, T.T, Benoit, E, Servent, D, Taylor, P, Molgo, J, Marchot, P. | Deposit date: | 2009-12-03 | Release date: | 2010-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural Determinants in Phycotoxins and Achbp Conferring High Affinity Binding and Nicotinic Achr Antagonism. Proc.Natl.Acad.Sci.USA, 107, 2010
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3LS4
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![BU of 3ls4 by Molmil](/molmil-images/mine/3ls4) | Crystal Structure of Anti-tetrahydrocannabinol Fab Fragment in Complex with THC | Descriptor: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, Heavy chain of antibody Fab fragment, Light chain of antibody Fab fragment | Authors: | Niemi, M.H, Rouvinen, J. | Deposit date: | 2010-02-12 | Release date: | 2010-06-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A structural insight into the molecular recognition of a (-)-Delta9-tetrahydrocannabinol and the development of a sensitive, one-step, homogeneous immunocomplex-based assay for its detection J.Mol.Biol., 400, 2010
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5KQZ
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![BU of 5kqz by Molmil](/molmil-images/mine/5kqz) | Protease E35D-CaP2 | Descriptor: | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, Protease | Authors: | Liu, Z, Poole, K.M, Mahon, B.P, McKenna, R, Fanucci, G.E. | Deposit date: | 2016-07-06 | Release date: | 2016-09-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291, 2016
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1ZRV
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![BU of 1zrv by Molmil](/molmil-images/mine/1zrv) | solution structure of spinigerin in H20/TFE 50% | Descriptor: | spinigerin | Authors: | Landon, C, Meudal, H, Boulanger, N, Bulet, P, Vovelle, F. | Deposit date: | 2005-05-23 | Release date: | 2005-10-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation. Biopolymers, 81, 2006
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6YNG
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![BU of 6yng by Molmil](/molmil-images/mine/6yng) | |
8G2M
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![BU of 8g2m by Molmil](/molmil-images/mine/8g2m) | The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer | Descriptor: | CITRIC ACID, Heavy chain of humanized IgG, Light chain of humanized IgG, ... | Authors: | Williams, J.C, Williams, J.C. | Deposit date: | 2023-02-05 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer, 11, 2023
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5G1X
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![BU of 5g1x by Molmil](/molmil-images/mine/5g1x) | Crystal structure of Aurora-A kinase in complex with N-Myc | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ... | Authors: | Richards, M.W, Burgess, S.G, Bayliss, R. | Deposit date: | 2016-03-31 | Release date: | 2016-11-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors Proc.Natl.Acad.Sci.USA, 113, 2016
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