PDB: 46006 resultsInfo pagesStatus searchChemie searchBIRD

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6FEC	Human cap-dependent 48S pre-initiation complex Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Schaffitzel, C, Schaffitzel, C. Deposit date: 2017-12-31 Release date: 2018-03-14 Last modified: 2018-10-03 Method: ELECTRON MICROSCOPY (6.3 Å) Cite: Structure of a human cap-dependent 48S translation pre-initiation complex. Nucleic Acids Res., 46, 2018
5AB9	Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole Descriptor: 7-ethyl-3-(piperidin-4-yl)-1H-indole, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... Authors: Joerger, A.C. Deposit date: 2015-08-04 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
5A7B	Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211 Descriptor: 2-[[4-(diethylamino)piperidin-1-yl]methyl]-6-ethynyl-4-(3-phenoxyprop-1-ynyl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION Authors: Joerger, A.C. Deposit date: 2015-07-03 Release date: 2015-09-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere. Acs Chem.Biol., 10, 2015
4DW6	Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis. Descriptor: AMMONIUM ION, GLYCEROL, HTH-type transcriptional regulator EthR, ... Authors: Flipo, M, Willand, N, Lecat-Guillet, N, Hounsou, C, Desroses, M, Leroux, F, Lens, Z, Villeret, V, Wohlkonig, A, Wintjens, R, Christophe, T, Jeon, H.K, Locht, C, Brodin, P, Baulard, A.R, Deprez, B. Deposit date: 2012-02-24 Release date: 2013-03-27 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. J.Med.Chem., 55, 2012
9F1S	Structure of UP1 S4ES6E phosphomimetic mutant Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-20 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of UP1 S4ES6E phosphomimetic mutant To Be Published
5VSZ	Structure of the Ubl domain of Sacsin mutant L78M Descriptor: Sacsin Authors: Trempe, J.-F, Pande, H, Shenker, S, Gehring, K. Deposit date: 2017-05-15 Release date: 2017-05-31 Last modified: 2018-08-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations. J. Biol. Chem., 293, 2018
7QGN	Structure of the SmrB-bound E. coli disome - stalled 70S ribosome Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Kratzat, H, Buschauer, R, Berninghausen, O, Beckmann, R. Deposit date: 2021-12-09 Release date: 2022-04-27 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature, 603, 2022
8CDL	80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... Authors: Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. Deposit date: 2023-01-31 Release date: 2023-09-20 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
8CDR	Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... Authors: Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. Deposit date: 2023-01-31 Release date: 2023-09-20 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.04 Å) Cite: mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
8CCS	80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... Authors: Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. Deposit date: 2023-01-27 Release date: 2023-09-20 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (1.97 Å) Cite: mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
7QQ3	Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A. Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... Authors: Koller, T.O, Beckert, B, Wilson, D.N. Deposit date: 2022-01-06 Release date: 2023-01-18 Last modified: 2023-02-01 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition. J.Am.Chem.Soc., 145, 2023
5AJ0	Cryo electron microscopy of actively translating human polysomes (POST state). Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. Deposit date: 2015-02-19 Release date: 2015-05-20 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural Snapshots of Actively Translating Human Ribosomes Cell(Cambridge,Mass.), 161, 2015
5NO3	RsgA-GDPNP bound to the 30S ribosomal subunit (RsgA assembly intermediate without uS3) Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Lopez-Alonso, J.P, Kaminishi, T, Kikuchi, T, Hirata, Y, Iturrioz, I, Dhimole, N, Schedlbauer, A, Hase, Y, Goto, S, Kurita, D, Muto, A, Zhou, S, Naoe, C, Mills, D.J, Gil-Carton, D, Takemoto, C, Himeno, H, Fucini, P, Connell, S.R. Deposit date: 2017-04-10 Release date: 2017-05-31 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (5.16 Å) Cite: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Res., 45, 2017
7Q4K	Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Fostier, C.R, Ousalem, F, Soufari, H, Leroy, E.C, Ngo, S, Innis, A, Hashem, Y, Boel, G. Deposit date: 2021-10-31 Release date: 2022-11-16 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Regulation of the macrolide resistance ABC-F translation factor MsrD. Nat Commun, 14, 2023
5NO4	RsgA-GDPNP bound to the 30S ribosomal subunit (RsgA assembly intermediate with uS3) Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Lopez-Alonso, J.P, Kaminishi, T, Kikuchi, T, Hirata, Y, Iturrioz, I, Dhimole, N, Schedlbauer, A, Hase, Y, Goto, S, Kurita, D, Muto, A, Zhou, S, Naoe, C, Mills, D.J, Gil-Carton, D, Takemoto, C, Himeno, H, Fucini, P, Connell, S.R. Deposit date: 2017-04-10 Release date: 2017-05-31 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (5.16 Å) Cite: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Res., 45, 2017
5NO2	RsgA-GDPNP bound to the 30S ribosomal subunit (RsgA assembly intermediate) Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Lopez-Alonso, J.P, Kaminishi, T, Kikuchi, T, Hirata, Y, Iturrioz, I, Dhimole, N, Schedlbauer, A, Hase, Y, Goto, S, Kurita, D, Muto, A, Zhou, S, Naoe, C, Mills, D.J, Gil-Carton, D, Takemoto, C, Himeno, H, Fucini, P, Connell, S.R. Deposit date: 2017-04-10 Release date: 2017-05-24 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (5.16 Å) Cite: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Res., 45, 2017
2XPU	TetR(D) in complex with anhydrotetracycline. Descriptor: 5A,6-ANHYDROTETRACYCLINE, CHLORIDE ION, SULFATE ION, ... Authors: Dalm, D, Palm, G.J, Hinrichs, W. Deposit date: 2010-08-30 Release date: 2011-09-07 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Tetracycline Repressor Allostery Does not Depend on Divalent Metal Recognition. Biochemistry, 53, 2014
7O7Z	Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot) Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... Authors: Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. Deposit date: 2021-04-14 Release date: 2021-06-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
7O80	Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... Authors: Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. Deposit date: 2021-04-14 Release date: 2021-06-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
7O81	Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... Authors: Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. Deposit date: 2021-04-14 Release date: 2021-06-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
7O7Y	Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution) Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... Authors: Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. Deposit date: 2021-04-14 Release date: 2021-06-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
8OR4	Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... Authors: Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. Deposit date: 2023-04-13 Release date: 2023-06-28 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
5ADY	Cryo-EM structures of the 50S ribosome subunit bound with HflX Descriptor: 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L10, ... Authors: Zhang, Y, Mandava, C.S, Cao, W, Li, X, Zhang, D, Li, N, Zhang, Y, Zhang, X, Qin, Y, Mi, K, Lei, J, Sanyal, S, Gao, N. Deposit date: 2015-08-25 Release date: 2015-10-14 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions Nat.Struct.Mol.Biol., 22, 2015
7C4J	Cryo-EM structure of the yeast Swi/Snf complex in a nucleosome free state Descriptor: Actin-like protein ARP9, Actin-related protein 7, Regulator of Ty1 transposition protein 102, ... Authors: Wang, C.C, Guo, Z.Y, Zhan, X.C, Zhang, X.F. Deposit date: 2020-05-18 Release date: 2020-07-15 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Structure of the yeast Swi/Snf complex in a nucleosome free state Nat Commun, 2020
2H09	Crystal structure of diphtheria toxin repressor like protein from E. coli Descriptor: Transcriptional regulator mntR Authors: Kumarevel, T.S, Tanaka, T, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-05-14 Release date: 2007-05-15 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the manganese transport regulatory protein from Escherichia coli. Proteins, 2009

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