PDB: 2579 resultsInfo pagesStatus searchChemie searchBIRD

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2C6I	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-10 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
2C6O	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: CELL DIVISION PROTEIN KINASE 2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-10 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg. Med. Chem. Lett., 16, 2006
2C6L	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-10 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
2C6T	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-11 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
2C6M	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-10 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
3HJ7	Crystal structure of TILS C-terminal domain Descriptor: CHLORIDE ION, tRNA(Ile)-lysidine synthase Authors: Nakanishi, K, Bonnefond, L, Kimura, S, Suzuki, T, Ishitani, R, Nureki, O. Deposit date: 2009-05-21 Release date: 2009-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. Nature, 461, 2009
8K5S	The structure of EntE with 3-(prop-2-yn-1-yloxy)benzoic acid sulfamoyl adenosine Descriptor: Enterobactin synthase component E, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-(3-prop-2-ynoxyphenyl)carbonylsulfamate Authors: Miyanaga, A, Ishikawa, F. Deposit date: 2023-07-24 Release date: 2024-07-31 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Reprogrammed aryl acid adenylation domain with an enlarged substrate binding pocket To be published
8K5T	The structure of EntE with2-methyl-3-chloro-benzoic acid sulfamoyl adenosine Descriptor: Enterobactin synthase component E, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-(3-chloranyl-2-methyl-phenyl)carbonylsulfamate Authors: Miyanaga, A, Ishikawa, F. Deposit date: 2023-07-24 Release date: 2024-07-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Reprogrammed aryl acid adenylation domain with an enlarged substrate binding pocket To be published
1I5O	CRYSTAL STRUCTURE OF MUTANT R105A OF E. COLI ASPARTATE TRANSCARBAMOYLASE Descriptor: ASPARTATE TRANSCARBAMOYLASE CATALYTIC CHAIN, ASPARTATE TRANSCARBAMOYLASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ... Authors: Macol, C.P, Tsuruta, H, Stec, B, Kantrowitz, E.R. Deposit date: 2001-02-28 Release date: 2001-05-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Direct structural evidence for a concerted allosteric transition in Escherichia coli aspartate transcarbamoylase. Nat.Struct.Biol., 8, 2001
4EQ5	DNA ligase from the archaeon Thermococcus sibiricus Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase Authors: Petrova, T, Bezsudnova, E.Y, Dorokhov, B.D, Slutskaya, E.S, Polyakov, K.M, Dorovatovskiy, P.V, Ravin, N.V, Skryabin, K.G, Kovalchuk, M.V, Popov, V.O. Deposit date: 2012-04-18 Release date: 2012-05-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable DNA ligase from the archaeon Thermococcus sibiricus. Acta Crystallogr.,Sect.F, 68, 2012
2NSY	CRYSTAL STRUCTURE OF NH3-DEPENDENT NAD+ SYNTHETASE FROM BACILLUS SUBTILIS IN COMPLEX WITH NAD-ADENYLATE Descriptor: ADENOSINE MONOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Rizzi, M, Bolognesi, M, Coda, A. Deposit date: 1998-07-14 Release date: 1999-01-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: A novel deamido-NAD+-binding site revealed by the trapped NAD-adenylate intermediate in the NAD+ synthetase structure. Structure, 6, 1998
2IVO	Structure of UP1 protein Descriptor: TUNGSTATE(VI)ION, UP1 Authors: Hecker, A, Leulliot, N, Graille, M, Dorlet, P, Quevillon-Cheruel, S, Ulryck, N, Van Tilbeurgh, H, Forterre, P. Deposit date: 2006-06-14 Release date: 2007-07-31 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: An Archaeal Orthologue of the Universal Protein Kae1 is an Iron Metalloprotein which Exhibits Atypical DNA-Binding Properties and Apurinic-Endonuclease Activity in Vitro. Nucleic Acids Res., 35, 2007
4L39	Crystal structure of GH3.12 from Arabidopsis thaliana in complex with AMPCPP and salicylate Descriptor: 2-HYDROXYBENZOIC ACID, 4-substituted benzoates-glutamate ligase GH3.12, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... Authors: Zubieta, C, Jez, J.M, Brown, E, Marcellin, R, Kapp, U, Round, A, Westfall, C. Deposit date: 2013-06-05 Release date: 2013-10-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Determination of the GH3.12 protein conformation through HPLC-integrated SAXS measurements combined with X-ray crystallography. Acta Crystallogr.,Sect.D, 69, 2013
3JZF	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series Descriptor: 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, Biotin carboxylase, CARBONATE ION Authors: Orth, P. Deposit date: 2009-09-23 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
1R0C	Products in the T State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-carbamyl-L-aspartate Ligated Enzyme Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-CARBAMOYL-L-ASPARTATE, ... Authors: Huang, J, Lipscomb, W.N. Deposit date: 2003-09-19 Release date: 2004-06-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Products in the T-State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-Carbamyl-l-aspartate Ligated Enzyme Biochemistry, 43, 2004
1WL8	Crystal structure of PH1346 protein from Pyrococcus horikoshii Descriptor: ACETIC ACID, CHLORIDE ION, GMP synthase [glutamine-hydrolyzing] subunit A Authors: Lokanath, N.K, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-06-21 Release date: 2005-08-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of Glutamide Amido Transferase from Pyrococcus horikoshii OT3 To be Published
6CN7	The structure of aerobactin synthetase IucC from a hypervirulent pathotype of Klebsiella pneumoniae Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Aerobactin synthase IucC Authors: Bailey, D.C, Rice, M.R, Gulick, A.M. Deposit date: 2018-03-07 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural and functional delineation of aerobactin biosynthesis in hypervirulentKlebsiella pneumoniae. J. Biol. Chem., 293, 2018
1RAE	CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Kosman, R.P, Gouaux, J.E, Lipscomb, W.N. Deposit date: 1992-08-14 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins, 15, 1993
1RAF	CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Kosman, R.P, Gouaux, J.E, Lipscomb, W.N. Deposit date: 1992-08-14 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins, 15, 1993
1RAD	CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Kosman, R.P, Gouaux, J.E, Lipscomb, W.N. Deposit date: 1992-08-14 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins, 15, 1993
1RAG	CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Kosman, R.P, Gouaux, J.E, Lipscomb, W.N. Deposit date: 1992-08-14 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins, 15, 1993
1RAC	CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Kosman, R.P, Gouaux, J.E, Lipscomb, W.N. Deposit date: 1992-08-14 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins, 15, 1993
3AX6	Crystal structure of N5-carboxyaminoimidazole ribonucleotide synthetase from Thermotoga maritima Descriptor: ADENOSINE-5'-DIPHOSPHATE, Phosphoribosylaminoimidazole carboxylase, ATPase subunit Authors: Miyazawa, R, Kanagawa, M, Baba, S, Nakagawa, N, Ebihara, A, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2011-03-30 Release date: 2012-04-25 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of N5-carboxyaminoimidazole ribonucleotide synthetase, PurK, from thermophilic bacteria To be Published
7DW7	Crystal Structure of N1051A mutant of Formylglycinamidine Synthetase Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Sharma, N, Tanwar, A.S, Anand, R. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase. Acs Catalysis, 12, 2022
1RAH	CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Kosman, R.P, Gouaux, J.E, Lipscomb, W.N. Deposit date: 1992-08-14 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins, 15, 1993

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