PDB: 224931 resultsInfo pagesStatus searchChemie searchBIRD

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4QRJ	Crystal structure of a putative 6-phosphogluconolactonase (BACUNI_04672) from Bacteroides uniformis ATCC 8492 at 2.20 A resolution Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, putative 6-phosphogluconolactonase Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-07-01 Release date: 2014-07-23 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of a putative 6-phosphogluconolactonase (BACUNI_04672) from Bacteroides uniformis ATCC 8492 at 2.20 A resolution To be published
4QR5	Brd4 Bromodomain 1 complex with its novel inhibitors Descriptor: Bromodomain-containing protein 4, N-[3-(cyclopentylsulfamoyl)-5-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]cyclopropanecarboxamide Authors: Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. Deposit date: 2014-06-30 Release date: 2015-07-01 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem., 58, 2015
4QRP	Crystal Structure of HLA B*0801 in complex with HSKKKCDEL and DD31 TCR Descriptor: Beta-2-microglobulin, DD31 TCR alpha chain, DD31 TCR beta chain, ... Authors: Gras, S, Berry, R, Lucet, I.S, Rossjohn, J. Deposit date: 2014-07-02 Release date: 2014-11-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant. J.Immunol., 193, 2014
4R5V	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor Descriptor: GLYCEROL, M1 family aminopeptidase, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ... Authors: Drinkwater, N, Mcgowan, S. Deposit date: 2014-08-22 Release date: 2014-10-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R7F	Crystal structure of a hypothetical protein (PARMER_01801) from Parabacteroides merdae ATCC 43184 at 2.30 A resolution Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2014-08-27 Release date: 2014-12-17 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of a hypothetical protein (PARMER_01801) from Parabacteroides merdae ATCC 43184 at 2.30 A resolution To be published
4QRT	Crystal Structure of HLA B*0801 in complex with ELN_YYM, ELNRKMIYM Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... Authors: Gras, S, Twist, K.-A, Rossjohn, J. Deposit date: 2014-07-02 Release date: 2014-07-16 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire. Sci Rep, 4, 2014
4QT7	Crystal structure of the c-Src SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Descriptor: NS5A, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Bacarizo, J. Deposit date: 2014-07-07 Release date: 2014-12-24 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure of the c-Src-SH3 domain in complex with a proline-rich motif of NS5A protein from the hepatitis C virus. J.Struct.Biol., 189, 2015
4QPN	Crystal Structure of Human Methyltransferase-Like Protein 21B Descriptor: Protein-lysine methyltransferase METTL21B, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... Authors: Tempel, W, Hong, B.S, Seitova, A, He, H, Li, Y, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) Deposit date: 2014-06-24 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal Structure of Human Methyltransferase-Like Protein 21B TO BE PUBLISHED
4QQ1	Crystal structure of the isotype 1 Transferrin binding protein B (TbpB) from serogroup B Neisseria meningitidis Descriptor: CESIUM ION, GLYCEROL, SULFATE ION, ... Authors: Calmettes, C, Moraes, T.F. Deposit date: 2014-06-26 Release date: 2015-04-01 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (3.33 Å) Cite: Patterns of structural and sequence variation within isotype lineages of the Neisseria meningitidis transferrin receptor system. Microbiologyopen, 4, 2015
4R0U	Tgvtava, an amyloid forming segment from alpha synuclein, residues 72-78 Descriptor: Alpha-synuclein Authors: Ivanova, M.I, Eisenberg, D.S, Sawaya, M.R. Deposit date: 2014-08-01 Release date: 2014-12-17 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Structure-based design of functional amyloid materials. J.Am.Chem.Soc., 136, 2014
4R53	dihydrodipicolinate synthase from C. jejuni with vacant active site and vacant allosteric site Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, CHLORIDE ION, ... Authors: Conly, C.J.T. Deposit date: 2014-08-20 Release date: 2015-10-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Tyrosine 110 plays a critical role in regulating the allosteric inhibition of Campylobacter jejuni dihydrodipicolinate synthase by lysine. Biochemistry, 53, 2014
4R1U	Crystal structure of Medicago truncatula cinnamoyl-CoA reductase Descriptor: ACETATE ION, Cinnamoyl CoA reductase Authors: Noel, J.P, Bomati, E.K, Louie, G.V, Bowman, M.E. Deposit date: 2014-08-07 Release date: 2014-10-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell, 26, 2014
4R2U	Crystal Structure of PPARgamma in complex with SR1664 Descriptor: 4'-[(2,3-dimethyl-5-{[(1S)-1-(4-nitrophenyl)ethyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, Peroxisome proliferator-activated receptor gamma Authors: Marciano, D.P, Kamenecka, T, Griffin, P.R, Bruning, J.B. Deposit date: 2014-08-13 Release date: 2015-07-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Pharmacological repression of PPAR gamma promotes osteogenesis. Nat Commun, 6, 2015
4RBT	PduA K26A S40L mutant, from Salmonella enterica serovar Typhimurium LT2 Descriptor: Propanediol utilization protein PduA, SULFATE ION Authors: Chun, S, Sawaya, M.R, Yeates, T.O. Deposit date: 2014-09-12 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Selective molecular transport through the protein shell of a bacterial microcompartment organelle. Proc.Natl.Acad.Sci.USA, 112, 2015
4RCG	Crystal Structure Analysis of MTB PEPCK without Mn+2 Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Brynda, J, Dostal, J, Snasel, J, Fanfrlik, J, Pichova, I, Machova, I. Deposit date: 2014-09-16 Release date: 2015-04-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Plos One, 10, 2015
4RCJ	Crystal structure of YTHDF1 YTH domain in complex with 5mer m6A RNA Descriptor: RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION, YTH domain-containing family protein 1 Authors: Tempel, W, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2014-09-16 Release date: 2014-11-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins. J.Biol.Chem., 290, 2015
4QRG	Crystal structure of I86L mutant of papain Descriptor: CHLORIDE ION, Papain, SODIUM ION Authors: Dutta, S, Choudhury, D, Roy, S, Biswas, S. Deposit date: 2014-07-01 Release date: 2015-08-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (2.497 Å) Cite: Pro-peptide regulates the substrate specificity and zymogen activation process of papain: A structural and mechanistic insight To be Published
4QRV	Crystal structure of I86F mutant of papain Descriptor: CHLORIDE ION, Papain, SODIUM ION Authors: Dutta, S, Choudhury, D, Roy, S. Deposit date: 2014-07-02 Release date: 2015-08-12 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.978 Å) Cite: Pro-peptide regulates the substrate specificity and zymogen activation process of papain: A structural and mechanistic insight to be published
4RF3	Crystal Structure of ketoreductase from Lactobacillus kefir, mutant A94F Descriptor: GLYCEROL, MAGNESIUM ION, NADPH dependent R-specific alcohol dehydrogenase Authors: Tang, Y, Tibrewal, N, Cascio, D. Deposit date: 2014-09-24 Release date: 2015-09-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.694 Å) Cite: Origins of stereoselectivity in evolved ketoreductases. Proc.Natl.Acad.Sci.USA, 112, 2015
4QTL	Crystal structure of human carbonic anhydrase isozyme II with inhibitor Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 2, ... Authors: Smirnov, A, Manakova, E, Grazulis, S. Deposit date: 2014-07-08 Release date: 2015-04-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases Chemmedchem, 10, 2015
4R8Z	Crystal Structure of PA4781 HD-GYP domain from Pseudomonas aeruginosa at 2.2A resolution showing a bi-metallic Ni ion center Descriptor: CHLORIDE ION, Cyclic di-GMP phosphodiesterase, NICKEL (II) ION Authors: Giardina, G, Cutruzzolaa, F, Rinaldo, S, Stelitano, V. Deposit date: 2014-09-03 Release date: 2015-03-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site. J.Bacteriol., 197, 2015
4R0P	Ifqins, an amyloid forming segment from human lysozyme spanning residues 56-61 Descriptor: Lysozyme C Authors: Sievers, S, Eisenberg, D.S, Sawaya, M.R. Deposit date: 2014-08-01 Release date: 2014-12-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Structure-based design of functional amyloid materials. J.Am.Chem.Soc., 136, 2014
4R0R	Ebolavirus GP Prehairpin Intermediate Mimic Descriptor: eboIZN21 Authors: Clinton, T.R, Weinstock, M.T, Jacobsen, M.T, Szabo-Fresnais, N, Pandya, M.J, Whitby, F.G, Herbert, A.S, Prugar, L.I, McKinnon, R, Hill, C.P, Welch, B.D, Dye, J.M, Eckert, D.M, Kay, M.S. Deposit date: 2014-08-01 Release date: 2014-10-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets. Protein Sci., 24, 2015
4R11	A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo Descriptor: Cadherin-related hmr-1, IODIDE ION, Protein humpback-2 Authors: Choi, H.-J, Loveless, T, Lynch, A, Bang, I, Hardin, J, Weis, W.I. Deposit date: 2014-08-03 Release date: 2015-04-29 Method: X-RAY DIFFRACTION (2.789 Å) Cite: A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo Dev.Cell, 33, 2015
4RDR	Structure of the bacterial Zn-transporter ZnuD from Neisseria meningitidis (locked conformation bound to zinc and cadmium ions) Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 1,2-ETHANEDIOL, CADMIUM ION, ... Authors: Calmettes, C, Moraes, T.F. Deposit date: 2014-09-19 Release date: 2015-08-19 Last modified: 2015-09-16 Method: X-RAY DIFFRACTION (2.472 Å) Cite: The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD. Nat Commun, 6, 2015

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