3S17
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![BU of 3s17 by Molmil](/molmil-images/mine/3s17) | RNA Polymerase II Initiation Complex with a 9-nt RNA | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-14 | Release date: | 2011-08-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3SGS
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3SH4
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![BU of 3sh4 by Molmil](/molmil-images/mine/3sh4) | |
3S5E
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![BU of 3s5e by Molmil](/molmil-images/mine/3s5e) | Crystal structure of human frataxin variant W155R, one of the Friedreich's ataxia point mutations | Descriptor: | Frataxin, mitochondrial, MAGNESIUM ION | Authors: | Tsai, C.-L, Bridwell-Rabb, J, Barondeau, D.P. | Deposit date: | 2011-05-23 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex. Biochemistry, 50, 2011
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3SI1
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![BU of 3si1 by Molmil](/molmil-images/mine/3si1) | Structure of glycosylated murine glutaminyl cyclase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutaminyl-peptide cyclotransferase, ZINC ION | Authors: | Dambe, T, Carrillo, D, Parthier, C, Stubbs, M.T. | Deposit date: | 2011-06-17 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center. Biochemistry, 50, 2011
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3SIY
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3SKG
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![BU of 3skg by Molmil](/molmil-images/mine/3skg) | Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3-isoquinolinyl)ethyl)-4-phenylbutanamide | Descriptor: | (2S)-2-[(3R)-3-(acetylamino)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-N-{(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]propan-2-yl}-4-phenylbutanamide, Beta-secretase 1 | Authors: | Muckelbauer, J.K. | Deposit date: | 2011-06-22 | Release date: | 2011-09-07 | Last modified: | 2012-12-05 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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3SL4
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![BU of 3sl4 by Molmil](/molmil-images/mine/3sl4) | Crystal structure of the catalytic domain of PDE4D2 with compound 10D | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Feil, S.F. | Deposit date: | 2011-06-24 | Release date: | 2011-10-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg.Med.Chem.Lett., 21, 2011
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3SMS
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![BU of 3sms by Molmil](/molmil-images/mine/3sms) | Human Pantothenate kinase 3 in complex with a pantothenate analog | Descriptor: | (2R)-N-[3-(heptylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, Pantothenate kinase 3, ... | Authors: | Mottaghi, K, Tempel, W, Hong, B, Smil, D, Bolshan, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-06-28 | Release date: | 2011-07-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Human Pantothenate kinase 3 in complex with a pantothenate analog to be published
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3SL6
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![BU of 3sl6 by Molmil](/molmil-images/mine/3sl6) | Crystal structure of the catalytic domain of PDE4D2 with compound 12c | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... | Authors: | Feil, S.F. | Deposit date: | 2011-06-24 | Release date: | 2011-10-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg.Med.Chem.Lett., 21, 2011
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3S0M
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![BU of 3s0m by Molmil](/molmil-images/mine/3s0m) | A Structural Element that Modulates Proton-Coupled Electron Transfer in Oxalate Decarboxylase | Descriptor: | 1,2-ETHANEDIOL, CARBONATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Saylor, B.T, Reinhardt, L.A, Lu, Z, Shukla, M.S, Cleland, W.W, Allen, K.N, Richards, N.G.J. | Deposit date: | 2011-05-13 | Release date: | 2012-04-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase. Biochemistry, 51, 2012
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3S12
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![BU of 3s12 by Molmil](/molmil-images/mine/3s12) | Crystal structure of H5N1 influenza virus hemagglutinin, strain YU562 crystal form 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... | Authors: | DuBois, R.M, Zaraket, H, Reddivari, M, Heath, R.J, White, S.W, Russell, C.J. | Deposit date: | 2011-05-14 | Release date: | 2011-12-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity. Plos Pathog., 7, 2011
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3S1M
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![BU of 3s1m by Molmil](/molmil-images/mine/3s1m) | RNA Polymerase II Initiation Complex with a 5-nt RNA (variant 1) | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*GP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | Deposit date: | 2011-05-15 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3RZY
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3S0C
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![BU of 3s0c by Molmil](/molmil-images/mine/3s0c) | Transaldolase wt of Thermoplasma acidophilum | Descriptor: | GLYCEROL, Probable transaldolase | Authors: | Lehwess-Litzmann, A, Neumann, P, Parthier, C, Tittmann, K. | Deposit date: | 2011-05-13 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism. Nat.Chem.Biol., 7, 2011
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3S38
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![BU of 3s38 by Molmil](/molmil-images/mine/3s38) | Structure of Thermus thermophilus cytochrome ba3 oxidase 30s after Xe depressurization | Descriptor: | COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, Cytochrome c oxidase subunit 1, ... | Authors: | Luna, V.M, Fee, J.A, Deniz, A.A, Stout, C.D. | Deposit date: | 2011-05-17 | Release date: | 2012-05-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Mobility of Xe atoms within the oxygen diffusion channel of cytochrome ba(3) oxidase. Biochemistry, 51, 2012
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3S5C
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![BU of 3s5c by Molmil](/molmil-images/mine/3s5c) | Crystal Structure of a Hexachlorocyclohexane dehydrochlorinase (LinA) Type2 | Descriptor: | LinA | Authors: | Kukshal, V, Macwan, A.S, Kumar, A, Ramachandran, R. | Deposit date: | 2011-05-23 | Release date: | 2012-05-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the hexachlorocyclohexane dehydrochlorinase (LinA-type2): mutational analysis, thermostability and enantioselectivity Plos One, 7, 2012
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3S1W
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![BU of 3s1w by Molmil](/molmil-images/mine/3s1w) | Transaldolase variant Lys86Ala from Thermoplasma acidophilum in complex with glycerol and citrate | Descriptor: | CITRATE ANION, GLYCEROL, Probable transaldolase | Authors: | Lehwess-Litzmann, A, Neumann, P, Parthier, C, Tittmann, K. | Deposit date: | 2011-05-16 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism. Nat.Chem.Biol., 7, 2011
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3S5P
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![BU of 3s5p by Molmil](/molmil-images/mine/3s5p) | |
3S2G
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![BU of 3s2g by Molmil](/molmil-images/mine/3s2g) | Crystal Structure of FurX NADH+:Furfuryl alcohol I | Descriptor: | FURFURAL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... | Authors: | Hayes, R, Sanchez, E.J, Webb, B.N, Hooper, T, Nissen, M.S, Li, Q, Xun, L. | Deposit date: | 2011-05-16 | Release date: | 2012-06-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures and furfural reduction mechanism of a bacterial zinc-dependent alcohol dehydrogenase To be Published
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3S5Y
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![BU of 3s5y by Molmil](/molmil-images/mine/3s5y) | Pharmacological Chaperoning in Human alpha-Galactosidase | Descriptor: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2011-05-23 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | The molecular basis of pharmacological chaperoning in human alpha-galactosidase Chem.Biol., 18, 2011
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3S3I
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![BU of 3s3i by Molmil](/molmil-images/mine/3s3i) | p38 kinase crystal structure in complex with small molecule inhibitor | Descriptor: | 3-(3-tert-butyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-4-methylbenzamide, Mitogen-activated protein kinase 14 | Authors: | Segarra, V, Aiguade, J, Roca, R, Fisher, M, Lamers, M. | Deposit date: | 2011-05-18 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Novel triazolopyridylbenzamides as potent and selective p38 alpha inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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3S4D
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![BU of 3s4d by Molmil](/molmil-images/mine/3s4d) | Lactose phosphorylase in a ternary complex with cellobiose and sulfate | Descriptor: | Lactose Phosphorylase, SULFATE ION, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Van Hoorebeke, A, Stout, J, Soetaert, W, Van Beeumen, J, Desmet, T, Savvides, S. | Deposit date: | 2011-05-19 | Release date: | 2012-06-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Cellobiose phosphorylase: reconstructing the structural itinerary along the catalytic pathway To be Published
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3S8G
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![BU of 3s8g by Molmil](/molmil-images/mine/3s8g) | 1.8 A structure of ba3 cytochrome c oxidase mutant (A120F) from Thermus thermophilus in lipid environment | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | Authors: | Tiefenbrunn, T, Liu, W, Chen, Y, Katritch, V, Stout, C.D, Fee, J.A, Cherezov, V. | Deposit date: | 2011-05-27 | Release date: | 2011-08-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment. Plos One, 6, 2011
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3S4Y
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![BU of 3s4y by Molmil](/molmil-images/mine/3s4y) | Crystal structure of human thiamin pyrophosphokinase 1 | Descriptor: | CALCIUM ION, SULFATE ION, THIAMINE DIPHOSPHATE, ... | Authors: | Shen, L, Tempel, W, Tong, Y, Li, Y, Walker, J.R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-05-20 | Release date: | 2011-06-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human thiamin pyrophosphokinase 1 to be published
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