8Y09
 
 | | Crystal structure of LbCas12a in complex with crRNA and 15nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*CP*TP*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LITHIUM ION, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y07
 | | Crystal structure of LbCas12a in complex with crRNA and 13nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LITHIUM ION, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y05
 | | Crystal structure of LbCas12a in complex with crRNA and 9nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LbCas12a, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y08
 | | Crystal structure of LbCas12a in complex with crRNA and 14nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*CP*TP*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LITHIUM ION, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.64 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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6URG
 | | Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 4, ... | | Authors: | Sun, Y, Zhang, Y, Walz, T, Tong, L. | | Deposit date: | 2019-10-23 | | Release date: | 2019-11-27 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery.
Mol.Cell, 77, 2020
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9AVR
 | | Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol | | Descriptor: | Eukaryotic initiation factor 4A-I, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Bhatt, G.B, Naineni, S.K, Cencic, R.C, Jiramongkolsiri, E.J, Huang, S.H, Pelletier, J.P, Nagar, B.N. | | Deposit date: | 2024-03-04 | | Release date: | 2024-10-23 | | Last modified: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.
Nucleic Acids Res., 52, 2024
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8Y0D
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9G1V
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G26
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site, closed state | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G27
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation state | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G23
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site bound to nucleotide analog AMPCPP at A-site | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G2B
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G24
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site bound to nucleotide analog AMPCPP at E-site | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G29
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site with the C-terminal of A12 in the funnel | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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9G2C
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site, open state | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA190, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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6OD8
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1AUD
 | | U1A-UTRRNA, NMR, 31 STRUCTURES | | Descriptor: | RNA 3UTR, U1A 102 | | Authors: | Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G. | | Deposit date: | 1997-08-22 | | Release date: | 1998-02-25 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural basis of the RNA-binding specificity of human U1A protein.
EMBO J., 16, 1997
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1RKJ
 | | Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target | | Descriptor: | 5'-R(*GP*GP*AP*UP*GP*CP*CP*UP*CP*CP*CP*GP*AP*GP*UP*GP*CP*AP*UP*CP*C)-3', Nucleolin | | Authors: | Johansson, C, Finger, L.D, Trantirek, L, Mueller, T.D, Kim, S, Laird-Offringa, I.A, Feigon, J. | | Deposit date: | 2003-11-21 | | Release date: | 2004-04-27 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target.
J.Mol.Biol., 337, 2004
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7VG3
 | | Cryo-EM structure of Arabidopsis DCL3 in complex with a 30-bp RNA | | Descriptor: | CALCIUM ION, Dicer-like 3, TAS1a RNA forward strand (5'-phosphorylated), ... | | Authors: | Wang, Q, Du, J. | | Deposit date: | 2021-09-14 | | Release date: | 2021-10-27 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation.
Science, 374, 2021
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7ROR
 | | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP | | Descriptor: | 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | | Deposit date: | 2021-08-02 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
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7ROS
 | | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ... | | Authors: | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | | Deposit date: | 2021-08-02 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
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5Y6L
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7ROT
 | | Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ... | | Authors: | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | | Deposit date: | 2021-08-02 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
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5GVZ
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9G1X
 | | Yeast RNA polymerase I elongation complex stalled by an apurinic site, 11-subunit | | Descriptor: | DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, DNA-directed RNA polymerase I subunit RPA190, ... | | Authors: | Santos-Aledo, A, Plaza-Pegueroles, A, Ruiz, F.M, Fernandez-Tornero, C. | | Deposit date: | 2024-07-10 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.
Nat Commun, 16, 2025
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