6K1E
| Crystal structure of EXD2 exonuclease domain soaked in Mg and GMP | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION | Authors: | Park, J, Lee, C. | Deposit date: | 2019-05-10 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. Nucleic Acids Res., 47, 2019
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6JUA
| Aspergillus oryzae pro-tyrosinase oxygen-bound C92A mutant | Descriptor: | COPPER (II) ION, PEROXIDE ION, Tyrosinase | Authors: | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | Deposit date: | 2019-04-13 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Copper-Oxygen Dynamics in the Tyrosinase Mechanism. Angew.Chem.Int.Ed.Engl., 59, 2020
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6JUP
| Mutant PolIV-DNA incoming nucleotide complex | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(P*CP*TP*GP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Nair, D.T, Johnson, M.K. | Deposit date: | 2019-04-15 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation. Nucleic Acids Res., 47, 2019
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6JV8
| Crystal structure of Rat C5a | Descriptor: | Complement C5 | Authors: | Zuo, C. | Deposit date: | 2019-04-16 | Release date: | 2020-04-22 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.582 Å) | Cite: | Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist To Be Published
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6JVG
| Crystal structure of human MTH1 in complex with compound MI0639 | Descriptor: | 5-ethyl-4-methyl-6-(morpholin-4-yl)pyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase | Authors: | Peng, C, Cheng, Y.S. | Deposit date: | 2019-04-17 | Release date: | 2020-10-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.844 Å) | Cite: | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
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6K1K
| Human nucleosome core particle with H2A.X S139E variant | Descriptor: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | Authors: | Sharma, D, De Falco, L, Davey, C.A. | Deposit date: | 2019-05-10 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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6JVQ
| Crystal structure of human MTH1 in complex with compound MI1025 | Descriptor: | 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-6-morpholin-4-yl-pyrimidine-2,4-diamine | Authors: | Peng, C, Li, Y.H, Cheng, Y.S. | Deposit date: | 2019-04-17 | Release date: | 2020-10-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.197 Å) | Cite: | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
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6JW2
| Universal RVD R* accommodates 5hmC via water-mediated interactions | Descriptor: | DNA (5'-D(*AP*GP*AP*GP*AP*CP*GP*CP*GP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*(5HC)P*GP*CP*GP*TP*CP*TP*CP*T)-3'), TAL effector | Authors: | Liu, L, Yi, C. | Deposit date: | 2019-04-18 | Release date: | 2020-04-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors. J.Mol.Biol., 432, 2020
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6JWZ
| Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with SDX-DHP | Descriptor: | 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ... | Authors: | Chitnumsub, P, Jaruwat, A, Yuthavong, Y. | Deposit date: | 2019-04-21 | Release date: | 2020-02-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
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6K1Y
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6K21
| Pyrophosphatase from Acinetobacter baumannii | Descriptor: | Inorganic pyrophosphatase, MAGNESIUM ION, SODIUM ION | Authors: | Su, J. | Deposit date: | 2019-05-13 | Release date: | 2019-10-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate. Int J Mol Sci, 20, 2019
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6K27
| Pyrophosphatase with PPi from Acinetobacter baumannii | Descriptor: | DIPHOSPHATE, Inorganic pyrophosphatase, MAGNESIUM ION | Authors: | Su, J. | Deposit date: | 2019-05-13 | Release date: | 2019-10-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate. Int J Mol Sci, 20, 2019
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6JXH
| K+-bound E2-MgF state of the gastric proton pump (Tyr799Trp) | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Abe, K, Irie, K. | Deposit date: | 2019-04-23 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A single K + -binding site in the crystal structure of the gastric proton pump. Elife, 8, 2019
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6JY5
| Structure of CsoS4B from Halothiobacillus neapolitanus | Descriptor: | Unidentified carboxysome polypeptide | Authors: | Zhao, Y.Y, Jiang, Y.L, Chen, Y, Zhou, C.Z, Li, Q. | Deposit date: | 2019-04-26 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of pentameric shell protein CsoS4B of Halothiobacillus neapolitanus alpha-carboxysome. Biochem.Biophys.Res.Commun., 515, 2019
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6JY9
| Structure of light-state marine bacterial chloride importer, NM-R3, with CW laser (ND-3%) at 95K. | Descriptor: | CHLORIDE ION, Chloride pumping rhodopsin, OLEIC ACID, ... | Authors: | Yun, J.H, Ohki, M, Park, S.Y, Lee, W. | Deposit date: | 2019-04-26 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family. Sci Adv, 6, 2020
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6K37
| Crystal structure of BioU (K124A) from Synechocystis sp.PCC6803 in complex with NAD+ and the analog of reaction intermediate, 3-(1-aminoethyl)-nonanedioic acid | Descriptor: | (3R)-3-[(1R)-1-azanylethyl]nonanedioic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Slr0355 protein | Authors: | Sakaki, K, Tomita, T, Nishiyama, M. | Deposit date: | 2019-05-16 | Release date: | 2020-02-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria. Nat.Chem.Biol., 16, 2020
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6QEC
| DNA binding domain of LUX ARRYTHMO in complex with DNA | Descriptor: | DNA (5'-D(*AP*TP*TP*CP*GP*AP*AP*TP*AP*T*TP*AP*TP*AP*TP*TP*CP*GP*AP*A)-3'), GLYCEROL, Transcription factor LUX | Authors: | Zubieta, C, Nayak, A. | Deposit date: | 2019-01-07 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular mechanisms of Evening Complex activity inArabidopsis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6K3E
| LSD1/Co-Rest structure with an inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-PCPA derivative, ... | Authors: | Wang, J. | Deposit date: | 2019-05-17 | Release date: | 2020-05-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | LSD1/Co-Rest structure with an inhibitor To Be Published
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6K3Q
| Crystal Structure of P450BM3 with N-(3-cyclohexylpropanoyl)-L-prolyl-L-phenylalanine | Descriptor: | (2S)-2-[[(2S)-1-(3-cyclohexylpropanoyl)pyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... | Authors: | Shoji, O, Yonemura, K. | Deposit date: | 2019-05-21 | Release date: | 2020-05-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 Acs Catalysis, 10, 2020
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6JYI
| Crystal structure of the PadR-like transcriptional regulator BC1756 from Bacillus cereus | Descriptor: | Transcriptional repressor PadR | Authors: | Kim, T.H, Park, S.C, Lee, K.C, Song, W.S, Yoon, S.I. | Deposit date: | 2019-04-26 | Release date: | 2019-06-26 | Last modified: | 2019-07-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural and DNA-binding studies of the PadR-like transcriptional regulator BC1756 from Bacillus cereus. Biochem.Biophys.Res.Commun., 515, 2019
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6JYQ
| Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide | Descriptor: | 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator | Authors: | Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M. | Deposit date: | 2019-04-27 | Release date: | 2020-05-13 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | H99Y-6F-HMA-pH7 To Be Published
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6JYW
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6JZ1
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6K4E
| SiaA-PP2C domain of Pseudomonas aeruginosa | Descriptor: | MAGNESIUM ION, Putative serine phosphatase | Authors: | Lin, J.Q, Lescar, J. | Deposit date: | 2019-05-23 | Release date: | 2019-06-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.094 Å) | Cite: | The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa. Plos One, 15, 2020
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6K4K
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