8XUM
 
 | | Structure of LGR4 with RSPO2 | | Descriptor: | Leucine-rich repeat-containing G-protein coupled receptor 4, MB52, R-spondin-2 | | Authors: | Wang, L, Geng, Y. | | Deposit date: | 2024-01-13 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | structure of LGR4 with RSPO2
To Be Published
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8XWN
 | | Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, MDNCF-a | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XVU
 | | Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 2 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-15 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XX7
 | | Structure of CXCR2 bound to CXCL5 (CXCR2-CXCL5-Go Full map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-17 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWA
 | | Structure of CXCR2 bound to CXCL1 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, Growth-regulated alpha protein | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWS
 | | Structure of CXCR2 bound to CXCL5 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 5 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XXH
 | | Structure of CXCR2 bound to CXCL2 (CXCR2-CXCL2-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, C-X-C motif chemokine 2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-18 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWM
 | | Structure of CXCR2 bound to CXCL6 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 6 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XXR
 | | Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-18 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XT9
 | | structure of LGR4 | | Descriptor: | Leucine-rich repeat-containing G-protein coupled receptor 4, MB52 | | Authors: | Wang, L, Geng, Y. | | Deposit date: | 2024-01-10 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | structure of LGR4
To Be Published
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8XX3
 | | Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, C-X-C motif chemokine 3, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-17 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XX6
 | | Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-17 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XQF
 | | Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13. | | Descriptor: | Apelin-13, G protein subunit alpha i1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-01-05 | | Release date: | 2025-01-22 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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8XXX
 | | Structure of CXCR2 bound to CXCL6 (Composite map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, C-X-C motif chemokine 6, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-19 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWV
 | | Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Growth-regulated alpha protein, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-22 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8Y63
 | | Cryo-EM structure of the C20:0 ceramide-bound FPR2-Gi complex | | Descriptor: | Cer(d18:0/20:0), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Sun, J.P, Jiang, C.T, Kong, W, Yu, X, Cai, K, Guo, L.L. | | Deposit date: | 2024-02-01 | | Release date: | 2025-02-05 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.
Science, 388, 2025
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8Y62
 | | Cryo-EM structure of the C16:0 ceramide-bound FPR2-Gi complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Sun, J.P, Jiang, C.T, Kong, W, Yu, X, Cai, K, Guo, L.L. | | Deposit date: | 2024-02-01 | | Release date: | 2025-02-05 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.
Science, 388, 2025
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8Y01
 | | Cryo-EM structure of Medium-wave-sensitive opsin 1 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Peng, Q, Jiang, H.H, Cheng, X.Y, Li, J, Zhang, J. | | Deposit date: | 2024-01-21 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Cryo-EM structure of Medium-wave-sensitive opsin 1
To Be Published
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8Y51
 | | Cryo-EM structure of the BRS3-Gq complex | | Descriptor: | Bombesin receptor subtype-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, C, Xu, Y, Yin, W, Xu, H.E. | | Deposit date: | 2024-01-31 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of self-activation and ligand recognition of human bombesin receptor subtype-3
To Be Published
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8Y0N
 | | Structure of CXCR3 in complex with VUF11418 and Go (Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-22 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.
Nat Commun, 16, 2025
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8XYK
 | | Structure of CXCR3 in complex with VUF10661 and Go (Full map) | | Descriptor: | (3~{S})-~{N}-[(2~{S})-6-azanyl-1-(2,2-diphenylethylamino)-1-oxidanylidene-hexan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1~{H}-isoquinoline-3-carboxamide, Antibody fragment ScFv16, C-X-C chemokine receptor type 3, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-19 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.
Nat Commun, 16, 2025
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8XXZ
 | | Structure of CXCR3 in the apo-state (Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-19 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.
Nat Commun, 16, 2025
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8Y6W
 | | TUG-1375 and 4-CMTB-bound human FFA2 in complex with Gi | | Descriptor: | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid, (2~{S})-2-(4-chlorophenyl)-3-methyl-~{N}-(1,3-thiazol-2-yl)butanamide, Free fatty acid receptor 2, ... | | Authors: | Kugawa, M, Kawakami, K, Kise, R, Kobayashi, K, Kojima, A, Inoue, W, Fukuda, M, Inoue, A, Kato, H.E. | | Deposit date: | 2024-02-03 | | Release date: | 2025-04-02 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2.
Nat Commun, 16, 2025
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8Y02
 | | Cryo-EM structure of Short-wave-sensitive opsin 1 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Peng, Q, Jiang, H.H, Cheng, X.Y, Li, J, Zhang, J. | | Deposit date: | 2024-01-21 | | Release date: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Cryo-EM structure of Short-wave-sensitive opsin 1
To Be Published
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8YRG
 | | CryoEM structure of fospropofol-bound MRGPRX4-Gq complex | | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Cao, C, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-03-21 | | Release date: | 2024-05-22 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.
Sci Transl Med, 16, 2024
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