PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

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3A0Z	Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 4: isopropanol, orthorombic) Descriptor: Sensor protein Authors: Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. Deposit date: 2009-03-25 Release date: 2009-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3C0E	Yeast Hsp82 N-terminal domain: effects of mutants 98-99 KS-AA Descriptor: ATP-dependent molecular chaperone HSP82 Authors: Immormino, R.M, Gewirth, D.T. Deposit date: 2008-01-19 Release date: 2008-07-29 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin To be Published
3C11	Yeast Hsp82 N-terminal domain-Geldanamycin complex: effects of mutants 98-99 KS-AA Descriptor: ATP-dependent molecular chaperone HSP82, GELDANAMYCIN, GLYCEROL Authors: Immormino, R.M, Gewirth, D.T. Deposit date: 2008-01-21 Release date: 2008-07-29 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin To be Published
3CGY	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain in complex with radicicol Descriptor: RADICICOL, Virulence sensor histidine kinase phoQ Authors: Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. Deposit date: 2008-03-06 Release date: 2008-05-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3CGZ	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain Descriptor: Virulence sensor histidine kinase phoQ Authors: Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. Deposit date: 2008-03-06 Release date: 2008-05-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3CRK	Crystal structure of the PDHK2-L2 complex. Descriptor: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, POTASSIUM ION, ... Authors: Green, T.J, Popov, K.M, Luo, M, Grigorian, A, Klyuyeva, A, Tuganova, A. Deposit date: 2008-04-07 Release date: 2008-04-29 Last modified: 2017-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2. J.Biol.Chem., 283, 2008
3CRL	Crystal structure of the PDHK2-L2 complex. Descriptor: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, MAGNESIUM ION, ... Authors: Popov, K.M, Luo, M, Green, T.J, Grigorian, A, Klyuyeva, A, Tuganova, A. Deposit date: 2008-04-07 Release date: 2008-04-29 Last modified: 2017-10-25 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2. J.Biol.Chem., 283, 2008
3D2R	Crystal structure of pyruvate dehydrogenase kinase isoform 4 in complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Kato, M, Wynn, R.M, Chuang, L.C, Tso, S.-C, Li, J, Chuang, D.T. Deposit date: 2008-05-08 Release date: 2008-08-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity. J.Biol.Chem., 283, 2008
3DGE	Structure of a histidine kinase-response regulator complex reveals insights into Two-component signaling and a novel cis-autophosphorylation mechanism Descriptor: ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, Response regulator, ... Authors: Casino, P, Marina, A. Deposit date: 2008-06-13 Release date: 2009-07-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction. Cell(Cambridge,Mass.), 139, 2009
3EHF	Crystal structure of DesKC in complex with AMP-PCP Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor kinase (YocF protein) Authors: Albanesi, D, Alzari, P.M, Buschiazzo, A. Deposit date: 2008-09-12 Release date: 2009-09-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
3EHG	Crystal structure of the ATP-binding domain of DesK in complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, IODIDE ION, MAGNESIUM ION, ... Authors: Trajtenberg, F, Buschiazzo, A. Deposit date: 2008-09-12 Release date: 2009-09-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase J.Biol.Chem., 285, 2010
3EHH	Crystal structure of DesKC-H188V in complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Sensor kinase (YocF protein) Authors: Albanesi, D, Alzari, P.M, Buschiazzo, A. Deposit date: 2008-09-12 Release date: 2009-09-15 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
3EHJ	Crystal structure of DesKC-H188V in complex with AMP-PCP Descriptor: CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor kinase (YocF protein) Authors: Albanesi, D, Alzari, P.M, Buschiazzo, A. Deposit date: 2008-09-12 Release date: 2009-09-15 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
3FV5	Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor Descriptor: 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea, DNA topoisomerase 4 subunit B Authors: Wei, Y, Charifson, P, LeTiran, A. Deposit date: 2009-01-15 Release date: 2010-01-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity To be Published
3G75	Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor Descriptor: 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole, DNA gyrase subunit B Authors: Wei, Y, Charifson, P. Deposit date: 2009-02-09 Release date: 2010-02-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3G7B	Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor Descriptor: DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate Authors: Wei, Y, Charisfon, P. Deposit date: 2009-02-09 Release date: 2010-02-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3G7E	Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor Descriptor: DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate Authors: Wei, Y, Charifson, P. Deposit date: 2009-02-09 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3GIE	Crystal structure of DesKC_H188E in complex with AMP-PCP Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor histidine kinase desK Authors: Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. Deposit date: 2009-03-05 Release date: 2009-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
3GIF	Crystal structure of DesKC_H188E in complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Sensor histidine kinase desK Authors: Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. Deposit date: 2009-03-05 Release date: 2009-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
3GIG	Crystal structure of phosphorylated DesKC in complex with AMP-PCP Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor histidine kinase desK Authors: Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. Deposit date: 2009-03-05 Release date: 2009-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.502 Å) Cite: Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
3H80	Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LmjF33.0312:M1-K213 Descriptor: 1,2-ETHANEDIOL, Heat shock protein 83-1, MAGNESIUM ION, ... Authors: Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, Mackenzie, F, Fairlamb, A, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) Deposit date: 2009-04-28 Release date: 2009-05-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LmjF33.0312:M1-K213 To be Published
3JA6	Cryo-electron Tomography and All-atom Molecular Dynamics Simulations Reveal a Novel Kinase Conformational Switch in Bacterial Chemotaxis Signaling Descriptor: Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein 2 Authors: Cassidy, C.K, Himes, B.A, Alvarez, F.J, Ma, J, Zhao, G, Perilla, J.R, Schulten, K, Zhang, P. Deposit date: 2015-04-21 Release date: 2015-12-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (12.7 Å) Cite: CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. Elife, 4, 2015
3JZ3	Structure of the cytoplasmic segment of histidine kinase QseC Descriptor: SULFATE ION, Sensor protein qseC Authors: Xie, W, Kwiatkowski, W, Choe, S, Center for Structures of Membrane Proteins (CSMP) Deposit date: 2009-09-22 Release date: 2010-07-21 Last modified: 2012-04-04 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the Cytoplasmic Segment of Histidine Kinase Receptor QseC, a Key Player in Bacterial Virulence. Protein Pept.Lett., 17, 2010
3K60	Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF07_0029) bound to ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 86, SULFATE ION Authors: Corbett, K.D, Berger, J.M. Deposit date: 2009-10-08 Release date: 2010-08-18 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins, 78, 2010
3LNU	Crystal structure of ParE subunit Descriptor: Topoisomerase IV subunit B Authors: Jung, H.Y, Heo, Y.-S. Deposit date: 2010-02-03 Release date: 2011-02-16 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of ParE subunit To be Published

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