8EYU
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![BU of 8eyu by Molmil](/molmil-images/mine/8eyu) | Structure of Beetroot dimer bound to DFAME | Descriptor: | POTASSIUM ION, RNA (49-MER), methyl (2E)-3-{(4Z)-4-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl}prop-2-enoate | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-10-28 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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8EYV
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![BU of 8eyv by Molmil](/molmil-images/mine/8eyv) | Structure of Beetroot dimer bound to DFHO | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, POTASSIUM ION, RNA (45-MER) | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-10-28 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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8F0N
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![BU of 8f0n by Molmil](/molmil-images/mine/8f0n) | Wobble Beetroot (A16U-U38G) dimer bound to DFHO | Descriptor: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, POTASSIUM ION, RNA (49-MER) | Authors: | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | Deposit date: | 2022-11-03 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun, 14, 2023
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2N68
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![BU of 2n68 by Molmil](/molmil-images/mine/2n68) | |
2LZQ
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![BU of 2lzq by Molmil](/molmil-images/mine/2lzq) | |
2MKB
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![BU of 2mkb by Molmil](/molmil-images/mine/2mkb) | |
2NTM
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![BU of 2ntm by Molmil](/molmil-images/mine/2ntm) | |
2NTK
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![BU of 2ntk by Molmil](/molmil-images/mine/2ntk) | Crystal structure of PurO/IMP from Methanothermobacter thermoautotrophicus | Descriptor: | IMP cyclohydrolase, INOSINIC ACID | Authors: | Kang, Y.N, Tran, A, White, R.H, Ealick, S.E. | Deposit date: | 2006-11-07 | Release date: | 2007-04-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase. Biochemistry, 46, 2007
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6RN1
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![BU of 6rn1 by Molmil](/molmil-images/mine/6rn1) | Structure of N-terminal truncated Plasmodium falciparum IMP-nucleotidase | Descriptor: | IMP-specific 5'-nucleotidase, putative | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-07 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RNH
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![BU of 6rnh by Molmil](/molmil-images/mine/6rnh) | Structure of C-terminal truncated Plasmodium falciparum IMP-nucleotidase | Descriptor: | GLYCEROL, IMP-specific 5'-nucleotidase, putative | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-08 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RMO
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![BU of 6rmo by Molmil](/molmil-images/mine/6rmo) | Structure of Plasmodium falciparum IMP-nucleotidase | Descriptor: | IMP-specific 5'-nucleotidase, putative | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-07 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RME
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![BU of 6rme by Molmil](/molmil-images/mine/6rme) | Structure of IMP bound Plasmodium falciparum IMP-nucleotidase mutant D172N | Descriptor: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-06 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RQR
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![BU of 6rqr by Molmil](/molmil-images/mine/6rqr) | Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of CFTR | Descriptor: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1,Cystic fibrosis transmembrane conductance regulator | Authors: | Martin, E.R, Ford, R.C, Robinson, R.C. | Deposit date: | 2019-05-16 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | In vivocrystals reveal critical features of the interaction between cystic fibrosis transmembrane conductance regulator (CFTR) and the PDZ2 domain of Na+/H+exchange cofactor NHERF1. J.Biol.Chem., 295, 2020
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6RMD
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![BU of 6rmd by Molmil](/molmil-images/mine/6rmd) | Structure of ATP bound Plasmodium falciparum IMP-nucleotidase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, IMP-specific 5'-nucleotidase, ... | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-06 | Release date: | 2020-07-15 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6LEM
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![BU of 6lem by Molmil](/molmil-images/mine/6lem) | Structure of E. coli beta-glucuronidase complex with C6-nonyl uronic isofagomine | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-2-nonyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid, Beta-D-glucuronidase | Authors: | Lin, H.-Y, Kuo, Y.-H, Lin, C.-H. | Deposit date: | 2019-11-25 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.188 Å) | Cite: | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4, 2021
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6LEG
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![BU of 6leg by Molmil](/molmil-images/mine/6leg) | Structure of E. coli beta-glucuronidase complex with uronic isofagomine | Descriptor: | (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid, Beta-D-glucuronidase | Authors: | Lin, H.-Y, Kuo, Y.-H, Lin, C.-H. | Deposit date: | 2019-11-25 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.603 Å) | Cite: | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4, 2021
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6LEJ
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![BU of 6lej by Molmil](/molmil-images/mine/6lej) | Structure of E. coli beta-glucuronidase complex with C6-propyl uronic isofagomine | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-2-propyl-piperidine-3-carboxylic acid, Beta-D-glucuronidase | Authors: | Lin, H.-Y, Kuo, Y.-H, Lin, C.-H. | Deposit date: | 2019-11-25 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.617 Å) | Cite: | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4, 2021
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6LEL
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![BU of 6lel by Molmil](/molmil-images/mine/6lel) | Structure of E. coli beta-glucuronidase complex with C6-hexyl uronic isofagomine | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-2-hexyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid, Beta-D-glucuronidase | Authors: | Lin, H.-Y, Kuo, Y.-H, Lin, C.-H. | Deposit date: | 2019-11-25 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. Commun Biol, 4, 2021
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1NFQ
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![BU of 1nfq by Molmil](/molmil-images/mine/1nfq) | Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Androsterone, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-15 | Release date: | 2002-12-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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6RMW
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![BU of 6rmw by Molmil](/molmil-images/mine/6rmw) | Structure of N-terminal truncated IMP bound Plasmodium falciparum IMP-nucleotidase | Descriptor: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | Deposit date: | 2019-05-07 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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1NFF
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![BU of 1nff by Molmil](/molmil-images/mine/1nff) | Crystal structure of Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-14 | Release date: | 2002-12-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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1NFR
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![BU of 1nfr by Molmil](/molmil-images/mine/1nfr) | Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-16 | Release date: | 2002-12-30 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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6MRN
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![BU of 6mrn by Molmil](/molmil-images/mine/6mrn) | Crystal Structure of ChlaDUB2 DUB domain | Descriptor: | Deubiquitinase and deneddylase Dub2 | Authors: | Hausman, J.M, Das, C. | Deposit date: | 2018-10-15 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | The Two Deubiquitinating Enzymes fromChlamydia trachomatisHave Distinct Ubiquitin Recognition Properties. Biochemistry, 59, 2020
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4IR4
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![BU of 4ir4 by Molmil](/molmil-images/mine/4ir4) | Crystal Structure of the bromodomain of human BAZ2B in complex with 1-[7-(morpholin-4-yl)-1-(pyridin-2-yl)indolizin-3-yl]ethanone (GSK2834113A) | Descriptor: | 1,2-ETHANEDIOL, 1-[7-(morpholin-4-yl)-1-(pyridin-2-yl)indolizin-3-yl]ethanone, Bromodomain adjacent to zinc finger domain protein 2B | Authors: | Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-01-14 | Release date: | 2013-01-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J.Med.Chem., 59, 2016
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4IR5
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![BU of 4ir5 by Molmil](/molmil-images/mine/4ir5) | Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone (GSK2847449A) | Descriptor: | 1,2-ETHANEDIOL, 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone, Bromodomain adjacent to zinc finger domain protein 2B | Authors: | Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-01-14 | Release date: | 2013-01-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J.Med.Chem., 59, 2016
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