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7A2V	Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E129Q at pH 4.0 Descriptor: Tyrosine-protein kinase Fyn Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E129Q at pH 4.0 To be published
7A37	Crystal structure of the c-Src SH3 domain mutant V111L-N113S-T114S in 3 M urea Descriptor: Proto-oncogene tyrosine-protein kinase Src, UREA Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Crystal structure of the c-Src SH3 domain mutant V111L-N113S-T114S in 3 M urea To be published
7A2Q	Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 3.0 with PEG Descriptor: SULFATE ION, TETRAETHYLENE GLYCOL, Tyrosine-protein kinase Fyn Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (0.94 Å) Cite: Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 3.0 with PEG To be published
7A33	Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 3.0 Descriptor: FORMIC ACID, Proto-oncogene tyrosine-protein kinase Src, SODIUM ION Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (0.96 Å) Cite: Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 3.0 To be published
7A2W	Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 3.0 Descriptor: CITRIC ACID, Tyrosine-protein kinase Fyn, VSL12 Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (0.99 Å) Cite: Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 3.0 To be published
7A3A	Intertwined dimer of the c-Src SH3 domain mutant V111L-N113S-T114S-Q128E at pH 6.0 Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, ... Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Intertwined dimer of the c-Src SH3 domain mutant V111L-N113S-T114S-Q128E at pH 6.0 To be published
7A2P	Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0 with PEG Descriptor: TRIETHYLENE GLYCOL, Tyrosine-protein kinase Fyn Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (0.9 Å) Cite: Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0 with PEG To be published
7A2N	Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Descriptor: FORMIC ACID, SODIUM ION, Tyrosine-protein kinase Fyn Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 To be published
7A2M	Crystal structure of the Fyn SH3 domain A95S-D99T mutant in C21 space group Descriptor: FORMIC ACID, SODIUM ION, SULFATE ION, ... Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of the Fyn SH3 domain A95S-D99T mutant in C21 space group To be published
7A2R	Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 6.0 Descriptor: Tyrosine-protein kinase Fyn Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2020-08-18 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 6.0 To be published
7JT9	Fgr SH3 domain crystal structure Descriptor: Tyrosine-protein kinase Fgr Authors: Perez, I, Berndt, S, Gurevich, V.V, Iverson, T.M. Deposit date: 2020-08-17 Release date: 2022-01-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.93 Å) Cite: A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr. J.Mol.Biol., 434, 2022
7CSR	Structure of Ephexin4 R676L Descriptor: Rho guanine nucleotide exchange factor 16 Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-17 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CSP	Structure of Ephexin4 IDPSH Descriptor: Rho guanine nucleotide exchange factor 16 Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-15 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CSO	Structure of Ephexin4 DH-PH-SH3 Descriptor: Rho guanine nucleotide exchange factor 16, SULFATE ION Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-15 Release date: 2021-02-24 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CFZ	SH3 domain of NADPH oxidase activator 1 Descriptor: NADPH oxidase activator 1 Authors: Kim, M, Park, J.H, Attri, P, Lee, W. Deposit date: 2020-06-29 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. Int.J.Biol.Macromol., 163, 2020
6XX2	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Cu(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.25 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX4	Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX3	Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Cu(II) at pH 6.5 co-crystallized with methyl beta-cyclodextrin Descriptor: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX5	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-05-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVO	Crystal structure of the intertwined dimer of the c-Src SH3 domain without ATCUN motif Descriptor: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVN	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 1 Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVM	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 2 Descriptor: GLYCEROL, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (0.9 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
5QU8	Crystal Structure of symmetric swapped human Nck SH3.1 domain, 0.93A, orthorhombic form IV Descriptor: Cytoplasmic protein NCK1, SODIUM ION Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (0.93 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU3	Crystal Structure of domain swapped human Nck SH3.1, 1.01A, monoclinic Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.02 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QUA	Crystal Structure of swapped human Nck SH3.1 domain, 1.5A, C2221 Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020

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