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9LDT	DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... Authors: Dunn, C.R, Holbrook, J.J, Muirhead, H. Deposit date: 1991-11-26 Release date: 1993-10-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
8UO2	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class R) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
3QD0	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide Descriptor: (3S,6R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ... Authors: Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. Deposit date: 2011-01-17 Release date: 2011-03-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
8UC3	Cryo-EM structure of the AlbAB cyclodipeptide oxidase enzyme filament Descriptor: Albonoursin synthase, FLAVIN MONONUCLEOTIDE, Protein AlbB Authors: Andreas, M.P, Giessen, T.W. Deposit date: 2023-09-25 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.78 Å) Cite: Cyclodipeptide oxidase is an enzyme filament. Nat Commun, 15, 2024
8UNQ	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class F) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNS	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8ZHA	HIV-1 integrase core domain in complex with compound 15 Descriptor: (2~{S})-2-[7-(cycloheptylcarbamoyl)-4',5-dimethyl-spiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, SULFATE ION, ... Authors: Furuzono, T, Orita, T, Nomura, A, Adachi, T. Deposit date: 2024-05-10 Release date: 2024-07-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg.Med.Chem.Lett., 2024
8UO4	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class T) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8ZH4	HIV-1 integrase core domain in complex with compound 5 Descriptor: (2~{S})-2-(4',5-dimethylspiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl)-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, SULFATE ION, ... Authors: Furuzono, T, Orita, T, Nomura, A, Adachi, T. Deposit date: 2024-05-10 Release date: 2024-07-10 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg.Med.Chem.Lett., 2024
8UNL	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class A) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNN	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UO3	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class S) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNX	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class M) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8XC1	C. elegans SID1 in complex with dsRNA Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gong, D.S. Deposit date: 2023-12-07 Release date: 2024-06-05 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.21 Å) Cite: Structural basis for double-stranded RNA recognition by SID1. Nucleic Acids Res., 52, 2024
8W9Z	The cryo-EM structure of the Nicotiana tabacum PEP-PAP Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta'', ... Authors: Wu, X.X, Zhang, Y. Deposit date: 2023-09-06 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structures of the plant plastid-encoded RNA polymerase. Cell, 187, 2024
3QGP	Crystal structure of IsdI in complex with heme and cyanide Descriptor: CYANIDE ION, Heme-degrading monooxygenase isdI, MAGNESIUM ION, ... Authors: Ukpabi, G.N, Murphy, M.E.P. Deposit date: 2011-01-24 Release date: 2011-07-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Heme Ruffling Enables the Catalytic Activity of the Heme Degrading Enzyme IsdI To be Published
8WA0	The cryo-EM structure of the Nicotiana tabacum PEP-PAP-TEC1 Descriptor: DNA (48-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wu, X.X, Zhang, Y. Deposit date: 2023-09-06 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Cryo-EM structures of the plant plastid-encoded RNA polymerase. Cell, 187, 2024
8UNP	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class E) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNY	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
9LDB	DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... Authors: Dunn, C.R, Holbrook, J.J, Muirhead, H. Deposit date: 1991-11-26 Release date: 1993-10-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
8UNO	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class D) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNM	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class B) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8XGY	Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION Authors: Li, G.-B, Wang, X.-Y. Deposit date: 2023-12-16 Release date: 2024-06-12 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (2.81 Å) Cite: X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 67, 2024
8UNV	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class K) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8Z10	Human beta-catenin crystal structure Descriptor: Catenin beta-1, PROLINE Authors: Tim, F. Deposit date: 2024-04-10 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of Beta-catenin To Be Published

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